Chronic moderate alcohol consumption induces iNOS expression in the penis: An immunohistochemical study

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0001-5848-3680
dc.authorid0000-0002-8472-0261
dc.authorscopusid6506175442
dc.authorscopusid23991887300
dc.authorscopusid11440747800
dc.authorscopusid56106423500
dc.authorscopusid7003362092
dc.authorscopusid57209429014
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidGONCA, Suheyla/F-6455-2018
dc.authorwosidYazır, YUSUFHAN/F-7289-2018
dc.authorwosidDalcik, Hakki/AAR-7464-2021
dc.contributor.authorGonca, Suheyla
dc.contributor.authorYazir, Yusufhan
dc.contributor.authorGöcmez, Semil Selcan
dc.contributor.authorDalcık, Ekim Nur
dc.contributor.authorUtkan, Tijen
dc.contributor.authorDalcık, Hakki
dc.date.accessioned2022-05-11T14:41:11Z
dc.date.available2022-05-11T14:41:11Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAim: To investigate the effect of moderate alcohol consumption on metabolic alterations, inducible nitric oxide synthase (iNOS), immunohistochemical distribution, and morphological damage to penile erectile tissue in rats. Materials and methods: Male Wistar albino rats were divided into 2 groups. Group 1 rats (control group, n = 8) received tap water ad libitum, and group 2 rats (n = 8) were fed with 20% ethanol. Increasing levels of alcohol were given to the rats over 12 weeks. Immunohistochemistry was then performed using the avidin-biotin-peroxidase technique on 5-mu m thickness tissue sections. Stained sections were examined by imaging microscope. Results: Alcohol consumption resulted in a significant increase in iNOS immunoreactivity in the penile erectile tissue. Increased iNOS expression was determined in the tunica albuginea, cavernosal smooth muscle cells, trabeculae of connective tissue, arterioles, and the urethral epithelium. Moreover, chronic alcohol consumption resulted in decreasing serum testosterone and high density lipoprotein (HDL) levels with increasing cholesterol and triglyceride levels. Conclusion: Chronic moderate alcohol consumption can affect penile erectile tissue by increasing iNOS immunoreactivity and induce histopathological damage such as penile fibrosis. These abnormalities are also related to the defense mechanism against morphological damage.
dc.description.sponsorshipKocaeli University, Kocaeli, TurkeyKocaeli University
dc.description.sponsorshipThis work was supported by the Research Fund of Kocaeli University, Kocaeli, Turkey.
dc.identifier.doi10.3906/sag-1303-102
dc.identifier.endpage380
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid25558636
dc.identifier.scopus2-s2.0-84897854696
dc.identifier.scopusqualityQ3
dc.identifier.startpage375
dc.identifier.urihttps://doi.org/10.3906/sag-1303-102
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9097
dc.identifier.volume44
dc.identifier.wosWOS:000334063700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöcmez, Semil Selcan
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic moderate alcohol consumption
dc.subjectiNOS
dc.subjectimmunohistochemistry
dc.subjectpenis
dc.subjectrat
dc.subjectNitric-Oxide Synthase
dc.subjectRabbit Corpus Cavernosum
dc.subjectEndothelium-Dependent Relaxation
dc.subjectSmooth-Muscle
dc.subjectL-Arginine
dc.subjectEthanol-Consumption
dc.subjectErectile Response
dc.subjectRat Penis
dc.subjectTissue
dc.titleChronic moderate alcohol consumption induces iNOS expression in the penis: An immunohistochemical study
dc.typeArticle

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