Spectrum of histopathological lesions in laparoscopic cholecystectomy specimens and incidental carcinoma rate: Our surgical and clinical experience
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce University Medical School
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Laparoscopic cholecystectomy (LC) has become the standard treatment method of cholelithiasis. The chronic cholecystitis and cholelithiasis are the most common pathologies seen in gallbladder disease, accompanying hyperplastic and dysplastic lesions. Methods: 568 laparoscopic cholecystectomy procedures performed between 2008-2013 were analyzed. Clinical details and histopathological data were retrieved from the records. The variety of morphological changes in the diseased gall bladder were correlated with the clinical findings. Chronic cholecystitis and cholelithiasis were put into two groups. A single sample when taken from each neck-corpus and fundus of the gallbladder in the first group, two samples were taken from each site and gallbladder was mapped and examined as a whole in the second group. Results: The sex distribution of the cases was 525 (92.4%) and 43 (7.6%) male (F/M: 12.1). Median age was 45.5 ± 12.7 years (range: 18-82), median operative time was 60.2 minutes (range: 17-200). Indications for surgery, were chronic cholecystitis in 525 (92.4%), acute cholecystitis in33 (4.4%), and gallbladder polyps in 6 (1%). Acalculous cholecystitis was present in 2 patient(% 0.35) who were operated. Most common pathology noted in our study was chronic cholecystitis seen in 442 cases (%74). Other benign lesions were cholesterosis in 36 (%6) and acute cholecystitis in 28 (%.4). Various other associated lesions and variants of cholecystitis were also encountered. A total of six malignant lesions of gallbladder were observed, which included six cases of incidental adenocarcinomas. By increasing the sample size in gallbladder we saw an increase in the rate of metaplasia (p=0,009), dysplasia (p=0,009), epithelial hyperplasia (p=0.003), and carsinoma (p=0.008) statistically. Conclusion: By increasing the sample size in gallbladder we saw an increase in the rate of metaplasia, dysplasia and carcinoma statistically. © 2012 Düzce Medical Journal.
Açıklama
Anahtar Kelimeler
Cholecystectomy, Gallbladder disease, Histopathology, acalculous cholecystitis, adult, age, aged, Article, cholecystectomy, cholecystitis, cholelithiasis, clinical examination, correlation analysis, female, gallbladder carcinoma, gallbladder disease, gallbladder dysplasia, gallbladder hyperplasia, gallbladder metaplasia, gallbladder polyp, gallbladder tumor, histopathology, human, incidental finding, major clinical study, male, medical record review, operation duration, sample size, sex ratio, treatment indication, very elderly
Kaynak
Duzce Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
17
Sayı
2
