The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas

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dc.authorid0000-0001-5590-0637
dc.authorscopusid56674583800
dc.authorscopusid55372092900
dc.authorscopusid56674439000
dc.authorscopusid55967340100
dc.authorscopusid6603952159
dc.authorscopusid7006006212
dc.authorwosidKARAARSLAN, Numan/I-6819-2019
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorGürbüz, Mehmet Sabri
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorAyan, Erdoğan
dc.contributor.authorVardar Aker, Fugen
dc.contributor.authorBerkman, Mehmet Zafer
dc.date.accessioned2022-05-11T14:34:46Z
dc.date.available2022-05-11T14:34:46Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractAIM: To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins-on the prognosis and biological behaviour of meningiomas. MATERIAL and METHODS: 79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system. RESULTS: Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity. CONCLUSION: In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas.
dc.identifier.doi10.5137/1019-5149.JTN.12807-14.1
dc.identifier.endpage683
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid27438616
dc.identifier.scopus2-s2.0-85017078100
dc.identifier.scopusqualityQ3
dc.identifier.startpage678
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.12807-14.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8089
dc.identifier.volume26
dc.identifier.wosWOS:000385338600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorÇalışkan, Tezcan
dc.institutionauthorAyan, Erdoğan
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGrade
dc.subjectKi-67 Proliferation index
dc.subjectMatrix Metalloproteinase-3
dc.subjectMeningioma
dc.subjectExpression
dc.subjectApoptosis
dc.subjectKi-67
dc.subjectAngiogenesis
dc.subjectRecurrence
dc.subjectTarget
dc.subjectRoles
dc.subjectMmp-9
dc.titleThe Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas
dc.typeArticle

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