The effects of kefi r, koumiss, yogurt and commercial probiotic formulations on PPAR a and PPAR- b / d expressions in mouse kidney

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dc.authorscopusid26640705000
dc.authorscopusid37121662100
dc.authorscopusid56577807500
dc.authorscopusid6701361197
dc.contributor.authorKaradağ Sarı, Ebru
dc.contributor.authorBakır, Buket
dc.contributor.authorAydın, B. D.
dc.contributor.authorSözmen, Mahmut
dc.date.accessioned2022-05-11T14:42:26Z
dc.date.available2022-05-11T14:42:26Z
dc.date.issued2014
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractCommercial probiotic capsules that contain probiotic bacteria, kefir, koumiss and yogurt contain beneficial microorganisms that affect cholesterol levels and immune response, and are used for treatment of some diseases. We investigated using immunohistochemistry the effects of kefir, koumiss, yogurt and a commercial probiotic formulation on the expression levels of peroxisome proliferator-Activated receptor-? (PPAR?) and peroxisome proliferator-Activated receptor-?/? (PPAR-?/?), which are members of the nuclear steroid hormone receptor superfamily in mouse kidney. Mice were assigned to five groups: group 1, commercial probiotic capsules; group 2, kefir; group 3, koumiss; group 4, yogurt; group 5, control. After oral administration for 15 days, body weights were recorded and kidney tissue samples were obtained. Hematoxylin & eosin staining and the streptavidin-biotin peroxidase complex (ABC) method were applied to tissue sections to examine histology and to determine the localization of PPAR? and PPAR-?/? in the kidneys. We found that the weights of the mice in the kefir, koumiss, yogurt and commercial probiotic capsules groups were increased compared to controls. No differences in kidney histology were observed in any of the experimental groups. Kefir, koumiss, yogurt and the commercial probiotic preparation increased PPAR? and PPAR-?/? expressions. © 2014 The Biological Stain Commission.
dc.description.sponsorshipThis Project was supported by the Commission for the Scientific Research Projects of Kafkas University, project number 2012-VF-5 Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
dc.identifier.doi10.3109/10520295.2013.844274
dc.identifier.endpage295
dc.identifier.issn1052-0295
dc.identifier.issue4en_US
dc.identifier.pmid24205877
dc.identifier.scopus2-s2.0-84921765709
dc.identifier.scopusqualityQ2
dc.identifier.startpage287
dc.identifier.urihttps://doi.org/10.3109/10520295.2013.844274
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9377
dc.identifier.volume89
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBakır, Buket
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKefir
dc.subjectKoumiss
dc.subjectPPAR-?/?
dc.subjectPPAR?
dc.subjectProbiotics
dc.subjectYogurt
dc.subjectperoxisome proliferator activated receptor delta
dc.subjectperoxisome proliferator activated receptor gamma
dc.subjectprobiotic agent
dc.subjectyoghurt
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdairy product
dc.subjectkidney
dc.subjectmale
dc.subjectmetabolism
dc.subjectmouse
dc.subjectoral drug administration
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectCultured Milk Products
dc.subjectKidney
dc.subjectMale
dc.subjectMice
dc.subjectPPAR delta
dc.subjectPPAR gamma
dc.subjectPPAR-beta
dc.subjectProbiotics
dc.subjectYogurt
dc.titleThe effects of kefi r, koumiss, yogurt and commercial probiotic formulations on PPAR a and PPAR- b / d expressions in mouse kidney
dc.typeArticle

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