The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats

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dc.authorscopusid56779839000
dc.authorscopusid55367802000
dc.authorscopusid6508093438
dc.authorscopusid16174252200
dc.authorscopusid57218420772
dc.authorwosidGurbuz, Muhammet Ali/AAA-4948-2022
dc.contributor.authorKöse, Duygu
dc.contributor.authorYüksel, Tuğba Nurcan
dc.contributor.authorHalıcı, Zekai
dc.contributor.authorÇadırcı, Elif
dc.contributor.authorGürbüz, Muhammed Ali
dc.date.accessioned2022-05-11T14:41:12Z
dc.date.available2022-05-11T14:41:12Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractObjective: We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods. Materials and Methods: In our experimental model, the 32 rats were divided into 4 groups: group 1: control group (HEALTHY); group 2: lipopolysaccharide group (LPS); group 3: LPS plus 50 mg/kg AGO group (LPS + AGO50); and group 4: LPS plus 100 mg/kg AGO group (LPS + AGO100). An LPS-induced sepsis model was performed to replicate the pathology of sepsis. Rats from all 4 groups were killed after 12 hours, and their lungs were quickly collected. To investigate the therapeutic strategy, we evaluated tumor necrosis factoralpha (TNF-alpha) and nuclear factor-kappa B (NF-kappa B) messenger RNA expressions by real-time polymerase chain reaction using molecular methods and lung tissue damage indicators using histopathological methods. Results: The expressions of TNF-alpha and NF-kappa B were reduced in the groups treated with AGO. The histopathology results supported the molecular results. Conclusion: In this experimental study, we demonstrated for the first time the positive effects of AGO on LPS-induced sepsis in lung tissue using molecular and histopathological methods, indicating that it contributes to the prevention of lung damage.
dc.identifier.doi10.5152/eurasianjmed.2021.20342
dc.identifier.endpage131
dc.identifier.issn1308-8742
dc.identifier.issue2en_US
dc.identifier.pmid34177296
dc.identifier.scopus2-s2.0-85108508720
dc.identifier.scopusqualityQ3
dc.identifier.startpage127
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2021.20342
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9106
dc.identifier.volume53
dc.identifier.wosWOS:000660311100011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYüksel, Tuğba Nurcan
dc.language.isoen
dc.publisherAves
dc.relation.ispartofEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSepsis
dc.subjectagomelatine
dc.subjecttumor necrosis factor-alpha
dc.subjectnuclear factor-kappa B
dc.subjectMelatonin Receptor
dc.subjectAnimal-Models
dc.subjectMt2 Receptors
dc.subjectSepsis
dc.subjectGenes
dc.titleThe Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats
dc.typeArticle

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