Spirulina platensis affects factors involved in spermatogenesis and increases ghrelin receptors in testis tissue of rats fed a high-fat diet

Basit Öğe Kaydı
dc.authorid0000-0002-7359-6568
dc.authorid0000-0001-7258-6862
dc.authorid0000-0002-1589-9229
dc.authorid0000-0001-9444-3598
dc.authorscopusid55834779800
dc.authorscopusid57115408300
dc.authorscopusid57126277600
dc.authorscopusid35788331200
dc.authorscopusid6603862675
dc.authorscopusid55971756000
dc.authorscopusid6505825773
dc.authorwosidArmutak, Elif/D-2901-2019
dc.authorwosidBILAL, TANAY/AAB-5566-2021
dc.authorwosidESENER, Osman Behzat Burak/D-1598-2019
dc.authorwosidGurevin, Ebru Gurel/AAC-7921-2020
dc.authorwosidBilal, Tanay/D-2596-2019
dc.contributor.authorEsener, Osman Behzat Burak
dc.contributor.authorGurel-Gürevin, E.
dc.contributor.authorIsbilen-Basok, B.
dc.contributor.authorYigit, F.
dc.contributor.authorBilal, T.
dc.contributor.authorAltiner, A.
dc.contributor.authorArmutak, Elif İlkay İkitimur
dc.contributor.authorYılmazer, Nadim
dc.date.accessioned2022-05-11T14:28:38Z
dc.date.available2022-05-11T14:28:38Z
dc.date.issued2017
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractGhrelin is a peptide hormone which plays important role in maintaining growth hormone release and energy homeostasis in vertebrates. Spirulina platensis (SP) has antioxidant and hypolipidemic effects due to its ingredients. In this study we aimed to investigate the effects of SP on the testicular structure and relation between ghrelin and testosterone in the testis of rats fed a high fat diet (HFD). Sixty four young adult male rats were used and divided to 8 equal groups. Experimental groups received addition of 10% cholesterol (CHL), 43% hydrogenated vegetable oil (HVO) and 3% SP alone or in combination to basal diet while the control group received only basal diet. Serum ghrelin and testosterone levels were measured with ELISA. Receptors for ghrelin and androgen were detected with immunohistochemistry. For histomorphometric investigation, tubulus seminiferus, intertubular area, tubulus seminiferus lumen, Leydig cell nucleus, Sertoli cell nucleus, germ cell nucleus, spermatocyte nucleus and elongated spermatid volume densities were determined stereologically. Serum ghrelin level was increased especially in HVO and CHL combination group compared to the control while serum ghrelin levels were close to control levels in SP-received groups. Ghrelin receptor level was increased in tubulus seminiferus with HVO+CHL administration but this effect was, however, limited in HVO+CHL and SP challenged groups. HVO+CHL administration caused a significant decrease in Leydig cell nucleus volume density, as well as in all SP-received groups, compared to the control. Significantly increased spermatocyte nucleus volume density in cholesterol-receiving groups was decreased to control level with SP alone and its combinations.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University, Istanbul, TurkeyIstanbul University [45753]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project No. 45753), Istanbul, Turkey.
dc.identifier.doi10.1515/pjvs-2017-0056
dc.identifier.endpage475
dc.identifier.issn1505-1773
dc.identifier.issn2300-2557
dc.identifier.issue3en_US
dc.identifier.pmid29166288
dc.identifier.scopus2-s2.0-85035329759
dc.identifier.scopusqualityQ3
dc.identifier.startpage467
dc.identifier.urihttps://doi.org/10.1515/pjvs-2017-0056
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6893
dc.identifier.volume20
dc.identifier.wosWOS:000411299400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmazer, Nadim
dc.language.isoen
dc.publisherPolska Akad Nauk, Polish Acad Sciences, Univ Warmia & Mazury Olsztyn
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGhrelin
dc.subjectSpirulina platensis
dc.subjecttestis
dc.subjectapoptosis
dc.subjectproliferation
dc.subjectInduced Obesity
dc.subjectSerum Testosterone
dc.subjectOxidative Stress
dc.subjectCell-Lines
dc.subjectExpression
dc.subjectHormone
dc.subjectPeptide
dc.subjectMice
dc.titleSpirulina platensis affects factors involved in spermatogenesis and increases ghrelin receptors in testis tissue of rats fed a high-fat diet
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
6893.pdf
Boyut:
15.95 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu