Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart

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dc.authorid0000-0002-7359-6568
dc.authorid0000-0002-9130-9518
dc.authorid0000-0001-5068-2968
dc.authorscopusid23975103000
dc.authorscopusid9243612600
dc.authorscopusid6505825773
dc.authorscopusid57185264300
dc.authorscopusid57204107057
dc.authorscopusid55040069600
dc.authorscopusid57218758010
dc.authorwosidArmutak, Elif/D-2901-2019
dc.contributor.authorÜstünova, Savaş
dc.contributor.authorTakır, Selçuk
dc.contributor.authorYılmazer, Nadim
dc.contributor.authorBulut, Huri
dc.contributor.authorAltındirek, Didem
dc.contributor.authorHatırnaz, Özden
dc.contributor.authorGürel Gürevin, Ebru
dc.date.accessioned2022-05-11T14:28:41Z
dc.date.available2022-05-11T14:28:41Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBackground/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other's production suggesting their interaction and cooperation in cardioprotection against I/R injury.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [31508, 55736, 47109]
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Istanbul University [grant numbers; 31508, 55736 and 47109].
dc.identifier.doi10.21873/invivo.12067
dc.identifier.endpage2516
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.issue5en_US
dc.identifier.pmid32871779
dc.identifier.scopus2-s2.0-85090182315
dc.identifier.scopusqualityQ2
dc.identifier.startpage2507
dc.identifier.urihttps://doi.org/10.21873/invivo.12067
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6910
dc.identifier.volume34
dc.identifier.wosWOS:000574979000007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmazer, Nadim
dc.language.isoen
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydrogen sulfide
dc.subjectnitric oxide
dc.subjectisolated heart
dc.subjectischemia/reperfusion injury
dc.subjectoxidative damage
dc.subjectIschemia-Reperfusion Injury
dc.subjectH2s Protects
dc.subjectSynthase
dc.subjectExpression
dc.subjectInhibition
dc.subjectFailure
dc.subjectHypertension
dc.subjectMice
dc.titleHydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart
dc.typeArticle

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