Application of ultrasound to the organic cornelian cherry (Cornus mas L.) vinegar: Changes in antibacterial, antidiabetic, antihypertensive, and anticancer activities

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dc.authoridYikmis, Seydi/0000-0001-8694-0658
dc.authorscopusid24483063300
dc.authorscopusid56811467400
dc.authorscopusid57672717400
dc.authorscopusid56497061100
dc.authorscopusid57202897863
dc.contributor.authorErdal, Berna
dc.contributor.authorAkalın, Ramadan Bilgin
dc.contributor.authorYılmaz, Bahar
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorYıkmış, Seydi
dc.date.accessioned2023-04-20T08:02:27Z
dc.date.available2023-04-20T08:02:27Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.departmentEnstitüler, Sağlık Bilimleri Enstitüsü, Tümör Biyolojisi ve İmmünolojisi Ana Bilim Dalı
dc.description.abstractIn this study, to determine their alternative/complementary properties, organic cornelian cherry vinegar samples prepared by traditional (CCV), thermal pasteurization (P-CCV), and ultrasound (UT-CCV) methods were tested for antibacterial, antidiabetic, antihypertensive, and anticancer activities. As a result of response surface methodology optimization, the bioactive compounds were increased. With ultrasound treatment, the total phenolic content increased by 4.6%. The antibacterial activity was detected in all samples, while the lowest MIC values (28.4 mu l/ml) in the presence of UT-CCV were found in Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus cereus, and Staphylococcus aureus. In addition, apoptosis was induced in HT-29 and MDA-MB-231 cells were treated with the CCV, P-CCV, and UT-CCV samples compared to the control group. It was determined that UT-CCV has antidiabetic and antihypertensive effects. Therefore, our study encourages further clinical research on the alternative/complementary property of cornelian cherry vinegar in the treatment of various health manifestations including infections, cancer, diabetes, and hypertension. Novelty Impact Statement Bioactive components of organic cornelian cherry vinegar increased with ultrasound treatment. Organic cornelian cherry vinegar stimulates apoptosis in cancer cells. Vinegar samples prepared by the UT-CCV method show better antibacterial activity compared to CCV and P-CCV samples.
dc.identifier.doi10.1111/jfpp.16952
dc.identifier.issn0145-8892
dc.identifier.issn1745-4549
dc.identifier.scopus2-s2.0-85135531129
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/jfpp.16952
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10940
dc.identifier.wosWOS:000835807900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErdal, Berna
dc.institutionauthorAkalın, Ramadan Bilgin
dc.institutionauthorYılmaz, Bahar
dc.institutionauthorYıkmış, Seydi
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Processing and Preservation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAscorbic-Acid
dc.subjectAntioxidant Activity
dc.subjectStrawberry Juice
dc.subjectWild Fruits
dc.subjectExtracts
dc.subjectAnthocyanins
dc.subjectSonication
dc.subjectProfiles
dc.subjectMulberry
dc.subjectQuality
dc.titleApplication of ultrasound to the organic cornelian cherry (Cornus mas L.) vinegar: Changes in antibacterial, antidiabetic, antihypertensive, and anticancer activities
dc.typeArticle

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