Effects of the prenatal administration of tetanus toxoid on the sociability and explorative behaviors of rat offspring: A preliminary study

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dc.authorscopusid57218290288
dc.authorscopusid55315126400
dc.authorscopusid29067508300
dc.authorscopusid57189713929
dc.authorscopusid57216297567
dc.authorscopusid55469991100
dc.contributor.authorSünnetçi, Eda
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorErdoğan, Mümin Alper
dc.contributor.authorAtasoy, Özüm
dc.contributor.authorErbaş, Aytun
dc.date.accessioned2022-05-11T14:05:09Z
dc.date.available2022-05-11T14:05:09Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its pathophysiology remains unclear. This issue is rendered more challenging by confounding data about the effects of vaccination on disease etiology. In this study, therefore, we investigated the neurodevelopmental effects of maternal tetanus toxoid administration on rat offspring. We hypothesized that the vaccine affects the sociability and preference for social novelty of rat offspring as well as the production of immunological and neurotrophic factors, including tumor necrosis factor-alfa (TNF-?), neuregulin-1 (NRG-1), neuron growth factor (NGF), and oxytocin. Methods: The study involved 12 female and 4 male adult Sprague-Dawley rats (238 ± 10 g), which were assigned to two groups. Group 1 (control group) was given 0.5 ml of normal saline (0.9% NaCl) on the 10th day of pregnancy, whereas Group 2 (experimental group) was administered 0.5 ml of tetanus vaccine (tetanus toxoid, 40 IU). Results: Maternal tetanus toxoid administration exerted beneficial effects on the sociability and explorative behaviors of the rats. The brain tissue levels of TNF-?, NGF, NRG-1, and oxytocin were higher in the experimental group than those among the controls. All these significant differences were found in both the male and female rats. Conclusion: This study is the first to demonstrate the advantages of tetanus toxoid administration in relation to the sociability and explorative behaviors of rat offspring. The results showed that the vaccine also influences NRG-1, neuregulin, and oxytocin production. © 2021 Korean College of Neuropsychopharmacology. All rights reserved.
dc.identifier.doi10.9758/CPN.2021.19.1.84
dc.identifier.endpage92
dc.identifier.issn1738-1088
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85101378231
dc.identifier.scopusqualityQ2
dc.identifier.startpage84
dc.identifier.urihttps://doi.org/10.9758/CPN.2021.19.1.84
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4906
dc.identifier.volume19
dc.identifier.wosWOS:000614138000008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherKorean College of Neuropsychopharmacology
dc.relation.ispartofClinical Psychopharmacology and Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutism
dc.subjectInflammation
dc.subjectNeurogenesis
dc.subjectTetanus
dc.subjectVaccination
dc.subjectnerve growth factor
dc.subjectneu differentiation factor
dc.subjectoxytocin
dc.subjecttetanus toxoid
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectbrain level
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectexploratory behavior
dc.subjectfemale
dc.subjectmale
dc.subjectnonhuman
dc.subjectopen field test
dc.subjectprenatal period
dc.subjectprogeny
dc.subjectrat
dc.subjectsocial behavior
dc.subjectsocial interaction
dc.titleEffects of the prenatal administration of tetanus toxoid on the sociability and explorative behaviors of rat offspring: A preliminary study
dc.typeArticle

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