Effects of the prenatal administration of tetanus toxoid on the sociability and explorative behaviors of rat offspring: A preliminary study
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean College of Neuropsychopharmacology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its pathophysiology remains unclear. This issue is rendered more challenging by confounding data about the effects of vaccination on disease etiology. In this study, therefore, we investigated the neurodevelopmental effects of maternal tetanus toxoid administration on rat offspring. We hypothesized that the vaccine affects the sociability and preference for social novelty of rat offspring as well as the production of immunological and neurotrophic factors, including tumor necrosis factor-alfa (TNF-?), neuregulin-1 (NRG-1), neuron growth factor (NGF), and oxytocin. Methods: The study involved 12 female and 4 male adult Sprague-Dawley rats (238 ± 10 g), which were assigned to two groups. Group 1 (control group) was given 0.5 ml of normal saline (0.9% NaCl) on the 10th day of pregnancy, whereas Group 2 (experimental group) was administered 0.5 ml of tetanus vaccine (tetanus toxoid, 40 IU). Results: Maternal tetanus toxoid administration exerted beneficial effects on the sociability and explorative behaviors of the rats. The brain tissue levels of TNF-?, NGF, NRG-1, and oxytocin were higher in the experimental group than those among the controls. All these significant differences were found in both the male and female rats. Conclusion: This study is the first to demonstrate the advantages of tetanus toxoid administration in relation to the sociability and explorative behaviors of rat offspring. The results showed that the vaccine also influences NRG-1, neuregulin, and oxytocin production. © 2021 Korean College of Neuropsychopharmacology. All rights reserved.
Açıklama
Anahtar Kelimeler
Autism, Inflammation, Neurogenesis, Tetanus, Vaccination, nerve growth factor, neu differentiation factor, oxytocin, tetanus toxoid, tumor necrosis factor, adult, animal experiment, Article, brain level, controlled study, drug effect, exploratory behavior, female, male, nonhuman, open field test, prenatal period, progeny, rat, social behavior, social interaction
Kaynak
Clinical Psychopharmacology and Neuroscience
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
19
Sayı
1
