Beneficial Effects of Quercetin on the Zone of Stasis in an Experimental Burn Model

Basit Öğe Kaydı
dc.authorid0000-0002-3053-9133
dc.authorscopusid16024976400
dc.authorscopusid35949526800
dc.authorscopusid57197076282
dc.authorscopusid23398341000
dc.authorwosidSahin, Ertan/AAG-8999-2020
dc.contributor.authorOrhan, Erkan
dc.contributor.authorŞahin, Ertan
dc.contributor.authorMetin, Melike Sapmaz
dc.contributor.authorTarladaçalışır, Yeter Topçu
dc.date.accessioned2022-05-11T14:36:53Z
dc.date.available2022-05-11T14:36:53Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractObjective: In burn injury, the zone of stasis determines the width and depth of the necrosis. Our aim is to show the effectiveness of quercetin on the viability within the zone of stasis in burns of rats. Materials and Methods: Forty-eight rats were divided into three groups. The rats in Group 1 (control group) were only applied the comb burn model; the rats in Group 2 (post-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day after the burn procedure until euthanasia; and the rats in Group 3 (pre-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day for 7 days before and after the burn procedure until euthanasia. Results: The living tissue calculated was 85.41% (+/- 14.06) in Group 3, 40.37% (+/- 9.75) in Group 2, and 16.81% (+/- 9.4) in Group 1. The level of apoptosis was 30.0 (+/- 10.8) in Group 3, 33.8 (+/- 08.7) in Group 2, and 37.4 (+/- 11.5) in Group 1. The level of autophagy was 49.50 (+/- 8.58) in Group 3, 27.17 (+/- 5.53) in Group 2, and 21.00 (+/- 5.66) in Group 1. All the differences between the groups were statistically significant (p< 0.01). Conclusion: Quercetin reduces apoptosis and increases autophagy, thereby increasing tissue viability in the zone of stasis of burn injury.
dc.description.sponsorshipNamik Kemal University Research Center [NKUBAP.00.20.AR.15.01]
dc.description.sponsorshipThe article was supported under project NKUBAP.00.20.AR.15.01 by the Namik Kemal University Research Center.
dc.identifier.doi10.5152/etd.2017.0164
dc.identifier.endpage130
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85056575378
dc.identifier.scopusqualityN/A
dc.identifier.startpage125
dc.identifier.urihttps://doi.org/10.5152/etd.2017.0164
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8453
dc.identifier.volume40
dc.identifier.wosWOS:000446895400003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorOrhan, Erkan
dc.language.isoen
dc.publisherAves
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectZone of stasis
dc.subjectquercetin
dc.subjectapoptosis
dc.subjectautophagy
dc.subjectReperfusion Injury
dc.subjectWound Progression
dc.subjectRats
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectIschemia
dc.subjectCells
dc.subjectNecrosis
dc.subjectTissue
dc.subjectRoles
dc.titleBeneficial Effects of Quercetin on the Zone of Stasis in an Experimental Burn Model
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8453.pdf
Boyut:
229.8 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu