Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study

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dc.authorscopusid57211591835
dc.authorscopusid55317577700
dc.authorscopusid56084894100
dc.authorscopusid37058172000
dc.authorscopusid16069377400
dc.contributor.authorKurtoğlu Özçağlayan, Tuğba İlkem
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorÖzçağlayan, Ömer
dc.contributor.authorTopçu, Birol
dc.contributor.authorÜnal, A.
dc.date.accessioned2022-05-11T14:07:42Z
dc.date.available2022-05-11T14:07:42Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractAim: Silent brain ischemia (SBI), defined as ischemic changes and infarcts without neurologic signs, is an established marker of poor survival. Magnetic resonance imaging (MRI) is useful to define SBI and white matter hyperintensities that correspond to microangipathic ischemic disease. This study aimed to investigate the relationship among SBI, white matter lesions and the extent of coronary artery disease (CAD), and to determine possible predictors of SBI. Material and Methods: A total 10640 patients who underwent coronary angiography were retrospectively screened to reveal 312 patients who had been evaluated with a subsequent cranial MRI within 6 months. CAD severity was established with Gensini score and MRIs were evaluated to determine presence of SBI and white matter hyperintensities scored by Fazekas. Finally, 58 patients with SBI and 254 without SBI consisted SBI and non-SBI groups. Results: Patients with SBI were significantly older with higher prevalence of male gender than the non-SBI patients. Both Gensini and Fazekas scores were higher in SBI-group (p<0.001). Fazekas score was positively correlated with Gensini score (r=0.219, p<0.001) and age (r=0.465, p<0.001). In the logistic regression analysis; age, male gender and Gensini score were identified as the independent predictors of SBI. Conclusion: Although SBIs don’t present neurological symptoms they are associated with poor survival and future stroke. Our data suggest that cranial MRI may be a screening tool in risk stratification, particularly in elderly male patients with multivessel CAD. Our study also depicted that age, male gender and high Gensini scores are the independent predictors of SBI. © 2020, Duzce University Medical School. All rights reserved.
dc.identifier.doi10.18678/dtfd.763145
dc.identifier.endpage206
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85098751002
dc.identifier.scopusqualityQ4
dc.identifier.startpage201
dc.identifier.urihttps://doi.org/10.18678/dtfd.763145
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5179
dc.identifier.volume22
dc.indekslendigikaynakScopus
dc.institutionauthorKurtoğlu Özçağlayan, Tuğba İlkem
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorÖzçağlayan, Ömer
dc.institutionauthorTopçu, Birol
dc.institutionauthorÜnal, A.
dc.language.isoen
dc.publisherDuzce University Medical School
dc.relation.ispartofDuzce Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBrain ischemia
dc.subjectCoronary angiography
dc.subjectCoronary artery disease
dc.subjectMagnetic resonance imaging
dc.subjectStroke
dc.subjectadult
dc.subjectaged
dc.subjectapparent diffusion coefficient
dc.subjectArticle
dc.subjectbrain ischemia
dc.subjectcardiovascular risk
dc.subjectcerebrospinal fluid
dc.subjectcoronary angiography
dc.subjectcoronary artery disease
dc.subjectcorpus callosum
dc.subjectdiffusion coefficient
dc.subjectdiffusion weighted imaging
dc.subjectfemale
dc.subjectfluid attenuated inversion recovery
dc.subjectGensini score
dc.subjectgray matter
dc.subjecthistopathology
dc.subjecthuman
dc.subjectimage analysis
dc.subjectmagnetic resonance angiography
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneutrophil lymphocyte ratio
dc.subjectnuclear magnetic resonance imaging
dc.subjectprevalence
dc.subjectreceiver operating characteristic
dc.subjectright coronary artery
dc.subjectrisk factor
dc.subjectscreening
dc.subjectsensitivity and specificity
dc.subjectwhite matter
dc.titleCranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study
dc.title.alternativeCranial magnetic resonance imaging as a screening tool for evaluation of silent brain ischemia in severe coronary artery disease: A clinical based study
dc.typeArticle

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