In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey

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dc.authoridyıldız kaya, sibel/0000-0002-6319-7889
dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoridYıldız, İlknur Esen/0000-0003-2987-0483
dc.authoridhızel, kenan/0000-0001-8644-139X
dc.authorwosidyıldız kaya, sibel/AAI-9667-2021
dc.authorwosidKarabay, Oguz/HHN-5893-2022
dc.authorwosidhızel, kenan/HHS-0134-2022
dc.authorwosidYıldız, İlknur Esen/AAR-3407-2021
dc.contributor.authorYıldırım, Figen Sarigul
dc.contributor.authorUser, Ülkü
dc.contributor.authorSarı, Nagehan Didem
dc.contributor.authorKurtaran, Behice
dc.contributor.authorÖnlen, Yusuf
dc.contributor.authorSenateş, Ebubekir
dc.contributor.authorGündüz, Alper
dc.contributor.authorKaraali, Rıdvan
dc.date.accessioned2023-05-06T17:23:32Z
dc.date.available2023-05-06T17:23:32Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naive patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization's objective of eliminating viral hepatitis.
dc.identifier.doi10.5152/tjg.2022.21834
dc.identifier.endpage978
dc.identifier.issn2148-5607
dc.identifier.issue11en_US
dc.identifier.pmid36415900
dc.identifier.scopus2-s2.0-85142524509
dc.identifier.scopusqualityQ3
dc.identifier.startpage971
dc.identifier.trdizinid1175267
dc.identifier.urihttps://doi.org/10.5152/tjg.2022.21834
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12123
dc.identifier.volume33
dc.identifier.wosWOS:000898674900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraali, Rıdvan
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal Of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDrug therapy
dc.subjectdrug users
dc.subjecthepatitis C virus
dc.subjectOpioid Agonist Treatment
dc.subjectVirus-Infection
dc.subjectGenotype Distribution
dc.subjectNatural-History
dc.subjectHcv
dc.subjectUsers
dc.subjectCoinfection
dc.subjectHiv
dc.subjectTherapy
dc.subjectSeroprevalence
dc.titleIn a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey
dc.typeArticle

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