Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats

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dc.contributor.authorSilici, Sibel
dc.contributor.authorOkan, Aslı
dc.contributor.authorKöklü, Betül
dc.contributor.authorDemiray, Sevim
dc.contributor.authorDoğanyiğit, Züleyha
dc.date.accessioned2023-05-06T17:23:46Z
dc.date.available2023-05-06T17:23:46Z
dc.date.issued2023
dc.departmentRektörlüğe Bağlı Bölümler, Rektörlük
dc.description.abstractBackground Propolis has become one of the most preferred supplements due to its beneficial biological properties. Organic (water and vegetable oils) and chemical (ethyl alcohol, propylene glycol, and glycerol) solvents are used for propolis extraction. However, the effects of these chemicals on health should be taken into account.Objectives In this study, the effects of propolis extracts on health were evaluated.Methods 32 pregnant Wistar albino rats and 64 neonatal/young adults were given three different extractions of propolis (propylene glycol, water, and olive oil). Histopathological analyses were performed on the liver and brain, and blood samples were taken from the hearts of rats.Results Histopathological scoring showed that the intensity of pycnotic hepatocyte, sinusoidal dilatation, and bleeding was high in liver samples of pregnant and baby rats given propylene glycol extract of propolis (p < 0.05). Propylene glycol extract caused dilatation of blood vessels and apoptosis of neurons in brain tissue. The histopathological score was significantly lower in liver and brain tissues of rats treated with water and olive oil extract compared to propylene propolis groups (p < 0.05). Liver enzyme levels in the blood increased in propylene propolis rats (p < 0.05).Conclusion Histopathological changes and biochemical alterations may indicate that propylene glycol extracts of propolis are more toxic than olive oil and water extracts. Therefore, olive oil and water extracts of propolis are more reliable than propylene glycol extract in pregnant and infant rats.
dc.description.sponsorshipErciyes University, Scientific Research Projects Unit [FCD-2021-10769]
dc.description.sponsorshipThis study was supported by the grant from Erciyes University, Scientific Research Projects Unit (Project code: FCD-2021-10769).
dc.identifier.doi10.1055/a-2010-4009
dc.identifier.issn0948-2393
dc.identifier.issn1439-1651
dc.identifier.pmid36889342
dc.identifier.scopus2-s2.0-85162931955
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1055/a-2010-4009
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12291
dc.identifier.wosWOS:000946151300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKöklü, Betül
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofZeitschrift Fur Geburtshilfe Und Neonatologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbrain
dc.subjectliver
dc.subjectpregnant rat
dc.subjectpropolis
dc.subjectsolvent
dc.subjectOlive Oil
dc.subjectOxidative Damage
dc.subjectBrain
dc.subjectInflammation
dc.subjectApoptosis
dc.subjectInjury
dc.subjectModel
dc.subjectAcid
dc.subjectDna
dc.titleToxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats
dc.typeArticle

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