DSpace Arşivi :: by Yazar "Özkan, Gülsüm" değerine göre listeleniyor

Yazar "Özkan, Gülsüm" seçeneğine göre listele

Listeleniyor 1 - 20 / 26

Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency
(Medical Assoc Nippon Medical Sch, 2018) Özkan, Gülsüm; Emeksiz, Gaye Kübra; Atar, Reşit Volkan; Sedef, Samet; Kara, Sonat Pınar; Öznur, Meltem; Turgut, Burhan
Purpura fulminans associated with antithrombin 3 (AT 3) deficiency is very rare in adults and neonates. It can be categorized into three principal forms - neonatal, idiopathic and acute infectious. Purpura fulminans has been reported to cause cardiac, pulmonary and renal damage in rare cases We describe an adult case of purpura fulminans developing in association with AT 3 deficiency without infection following a surgical procedure, and acute kidney injury (AKI) developing secondary to rhabdomyolysis and disseminated intravascular coagulation (DIC). To the best of our knowledge there have been no previous cases of purpura fulminans and AKI developing in association with acquired AT 3 deficiency without infection after surgery.
Carbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results
(Verduci Editore s.r.l, 2021) Kara, Sonat Pınar; Özkan, Gülsüm; Emeksiz, Kübra; Menteşe, A.; Demir, S.; Ulusoy, S.
OBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. © 2020 Verduci Editore s.r.l. All rights reserved.
COVID-19 Pandemisinde Nefroloji Kliniklerinin Yönetimi
(2020) Bayrakçı, Nergiz; Özkan, Gülsüm
SARS-COV2’nin etkeni olduğu COVİD-19 ciddi mortaliteye sebep olan, Dünya Sağlık Örgütü tarafından kısa süre içinde pandemi olarak ilan edilen bir hastalık halini almıştır. Semptomatik olguların büyük kısmında hastalık hafif semptomlarla geçirilse de bazı hastaların mortalite ve morbidite açısından daha yüksek risk grubunda oldukları görülmüştür. Hipertansiyon başta olmak üzere kronikkardiyovasküler hastalığı olan hastalar ve glomerülonefritler, renal tranplantasyon ve diğer sebeplere bağlı kronik böbrek hastalıklarını içeren kronik renal hastalığı olanlar bahsi geçen yüksek risk grubundadır. Öte yandan böbrekler COVİD-19 seyrinde akut biçimde de en sık ve ağır biçimde etkilenen organlar arasında yer almaktadır. Hastalığın kesin bir tedavisinin olmaması, etkilenen organlarda uzunvadedeki etkilerinin bilinmemesi nedeniyle koruyucu önlemler COVİD-19 pandemisinin yönetiminde kilit role sahiptir. Tüm bu özelliklerinden ötürü COVİD-19 pandemisi nefroloji kliniklerinde özel koruyucu önlemler alınmasını, tedavi ve takipte kısa ve uzun vadeli planlamalar yapılmasını gerekli kılmıştır. Bu makalede COVİD-19 pandemisinde nefroloji kliniklerinde yapılması gereken düzenlemeler ve özel hasta gruplarının takibi özetlenecektir.
DİABETİK NEFROPATİ VE UYKU APNE SENDROMUNA SEKONDER DİRENÇLİ HİPERTANSİYON OLGUSU
(Namık Kemal Üniversitesi, Tıp Fakültesi, 2016) Bayır, Duygu; Özkan, Gülsüm
Dirençli hipertansiyon günlük pratikte yaygın görülen bir problemdir. Yapılan çalışmalarda görülme sıklığı %15 ile %27 arasında değişmektedir. Uygun doz ve kombinasyonda çoklu antihipertansif kullanımına rağmen dirençli hipertansiyonu olan hastaların kontrollü hipertansiyon hastalarına göre kardiyovasküler hastalık riskleri artmıştır. Antihipertansif tedaviye direnç yalancı yada gerçek olabilir. Bu hastalar değerlendirilirken öncelikle yalancı dirençli hipertansiyon nedenlerini dışlamak ve sonrasında dirençli hipertansiyona neden olabilecek faktörleri tek tek gözden geçirmek gerekecektir. Tedavi yalancı direncin dışlanması, hipertansiyona katkıda bulunan faktörlerin ve/ veya sekonder hipertansiyon (HT) sebeplerinin belirlenmesi ve düzeltilmesi, yaşam tarzı değişikliklerinin uygulanması ve etkili çoklu ilaç kullanımından ibarettir. Altta yatan neden doğru bir şekilde saptandığında, tedavi şansı daha yüksek olacak , hastaların gereksiz ilaç kullanımı , komplikasyonlara maruz kalma oranları ve mali yük azaltılmış olacaktır. Biz bu vakayı takip sürecinde HT etyolojisi iyi araştırılmadığı için çoklu antihipertansif ilaç kullanımına rağmen kan basıncının regüle olmaması nedeni ile tartışmak istedik.
Do Physicians Measure Patients' Blood Pressure, and Are Those Measurements Reliable?
(Springernature, 2018) Ulusoy, Şükrü; Özkan, Gülsüm; Güvercin, Beyhan; Sökmen, Yeliz; Erdem, Yunus
To determine how and how often blood pressure (BP) measurement is performed in health institutions. The researchers observed whether or not 84 physicians performed BP measurement. Immediately after BP measurement by the physician, this was repeated by the researchers in a manner compatible with HT guidelines. The physicians' and researchers' BP measurement results were compared. Physicians measured BP in only 37% (427) of 1130 consecutive patient examinations. None of the physicians BP measurements were fully compatible with the guidelines BP measurement recommendations. Physicians who performed measurements determined the same SBP and DBP as the researchers in 34.3% of patients. Hypertension was determined in 18.9% of patients in clinics in which BP measurement was not performed by physicians. Not all physicians in our study measured BP, and the great majority of those who did failed to measure it reliably. We think that it is therefore vitally important for physicians across the world to receive regular, repeated, and effective training in the importance of BP measurement and how to perform it correctly.
Do Physicians Measure Patients' Blood Pressure, and Are Those Measurements Reliable? (Meeting Abstract)
(Lippincott Williams & Wilkins, 2018) Şükrü, Ulusoy; Özkan, Gülsüm; Güvercin, Beyhan; Sökmen, Yeliz; Erdem, Yunus
[No Abstract Available]
Does Blood Pressure Variability Affect Hypertension Development in Prehypertensive Patients?
(NLM (Medline), 2022) Özkan, Gülsüm; Ulusoy, Şükrü; Arıcı, Mustafa; Derici, Ülver; Akpolat, T.; Şengül, Şule; Erdem, Yunus
BACKGROUND: Blood pressure variability (BPV) is associated with end organ damage and cardiovascular outcomes in hypertensive patients. Prehypertensive patients frequently develop hypertension (HT). The purpose of the present study was to evaluate the effect of BPV on the development of HT. METHODS: Two hundred and seven prehypertensive patients from the Cappadocia cohort were monitored over 2 years, and 24-hour ambulatory blood pressure monitoring (ABPM), office BP, and home BP measurements were subsequently performed at 4- to 6-month intervals. BPV was calculated as average real variability (ARV) from 24-h ABPM data, home BP, and office BP measurements at first visit. The relationship was evaluated between baseline ARV and the development of HT. RESULTS: HT was diagnosed in 25.60% of subjects. Baseline 24-hour ABPM systolic blood pressure (SBP)ARV and diastolic blood pressure (DBP)ARV and home SBPARV were significantly higher in patients who developed HT than the other patients (P 0.006, 0.001 and 0.006, respectively). Baseline 24-hour ABPM SBPARV and home SBPARV exceeding the 90th percentile were identified as parameters affecting development of HT at logistic regression analysis. CONCLUSION: In conclusion, our prospective observational cohort study showed that short-term BPV in particular can predict the development of HT in the prehypertensive population. © American Journal of Hypertension, Ltd 2021. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Down-regulation of miRNA 145 and up-regulation of miRNA 4516 may be associated with primary hypertension
(Wiley, 2019) Özkan, Gülsüm; Ulusoy, Şükrü; Geyik, Elif; Erdem, Yunus
Complex mechanisms including genetic factors have been proposed in the pathogenesis of primary hypertension (HT). Micro RNAs (miRNAs) are single-stranded RNA molecules that are not converted into protein products. However, it has been established that genes regulate conversion into protein products. The primary aim of this study was to investigate the roles of miRNA 4516, miRNA 145, miRNA 24, and miRNA 181a in the pathogenesis of HT. The secondary aim was to investigate the relation between these miRNAs and renin, aldosterone, norepinephrine, renalase, and NOS. Fifty-two hypertensive and 51 control normotensive individuals under observation in the Cappadocia cohort were included in the study. miRNA 4516, miRNA 181a, miRNA 24, and miRNA 145 levels were measured using the ddPCR method. miRNA 4516 and norepinephrine levels were significantly higher in the HT group (P < .005 for both), while miRNA 145 levels were significantly lower (<.05). miRNA 4516 up-regulation (P < .05) and miRNA 145 down-regulation (P < .05) were identified as independent predictors of HT. Renalase exhibited negative correlation with miRNA 4516 and positive correlation with miRNA 145 in the patient and control group. In addition, negative correlation was present between miRNA 24 and NE and NOS and between miRNA 181a and NOS in the patient group. Our study identified, for the first time in the literature, miRNA 4516 up-regulation and miRNA 145 down-regulation as independent determinants of HT. Further studies performed in the light of our findings may lead to a better understanding of the pathogenesis and new therapeutic possibilities.
Elevated serum levels of procollagen C-proteinase enhancer-1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate
(Wiley, 2019) Özkan, Gülsüm; Güzel, Savaş; Atar, Reşit Volkan; Fidan, Çiğdem; Kara, Sonat Pınar; Ulusoy, Şükrü
Background Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55 kDa glycoprotein, which increases the activity of procollagen C-proteinases that break down C-terminal propeptides. Studies have shown that PCPE-1 is involved in the fibrotic process that occurs in various tissues and organs. Our review of the literature revealed no data concerning the relation between PCPE-1 and chronic kidney disease (CKD). The purpose of this study was to determine PCPE-1 levels in CKD. Methods One hundred thirty-one CKD patients and 34 healthy controls were included in our study. Demographic data were recorded, and routine biochemical tests were performed. Blood specimens were collected for PCPE-1 investigation. Demographic data, biochemical test results and PCPE-1 levels were compared between the control and patient groups. Parameters affecting PCPE-1 levels in our patient group were assessed. Results Procollagen C-proteinase enhancer-1 levels were significantly higher in our patient group compared to the control group. Parameters affecting PCPE-1 elevation in the patient group were identified as systolic blood pressure, blood urea nitrogen, phosphorus, haemoglobin, intact parathormone levels, glomerular filtration rate and body mass index. Conclusion We determined high PCPE-1 levels in CKD patients. PCPE-1 levels being negatively correlated with glomerular filtration rate suggests that PCPE-1 may be associated with progression in CKD patients.
KRONİK BÖBREK YETMEZLİĞİ HASTALARINDA HEMODİYALİZ GİRİŞİ İÇİN OLUŞTURULAN KALICI DAMAR YOLLARININ AÇIK KALMA SÜRELERİNİN BELİRLENMESİ VE BU SÜREYE ETKİSİ OLAN FAKTÖRLERİN ARAŞTIRILMASI
(Namık Kemal Üniversitesi, Tıp Fakültesi, 2016) Tomar, Özdem Kavraz; Ulusoy, Şükrü; Pulathan, Zerrin; Kaynar, Kübra; Özkan, Gülsüm
Amaç: Kronik böbrek yetersizliği tanısıyla hemodiyaliz planlanan ve kalıcı damar yolu oluşturulan hastalarda, bu kalıcı damar yollarının (arteriovenöz fistül (AVF), arteriovenöz greft (AVG) ve kalıcı kateter) patenslerinin belirlenmesi ve bu Patensi etki eden faktörlerin tespit edilip bu sayede bundan sonra oluşturulacak olan kalıcı damar yolu patenslerinin uzatılmasına katkı sağlamaktır. Materyal ve Metod: Çalışmamıza KTÜ Nefroloji kliniğinde Kronik Böbrek Yetmezliği tanısıyla takip edilen, KTÜ Tıp Fakültesi Göğüs Kalp Damar Cerrahisi kliniği cerrahları tarafından kalıcı hemodiyaliz girişi oluşturulması amacıyla AVF, AVG ve kalıcı kateter uygulanan ve arşivinden dosyalarına ulaşılabilen 18 yaş ve üzeri, 420 hasta alındı. Hastaların biyokimyasal, hematolojik ve demografik verileri kaydedildi. Bu parametrelerin vasküler erişim yolu patensi üzerine etkisi analiz edildi. Bulgular: Çalışmamızda kalıcı damar yolu oluşturulan 420 KBY hastasının % 86’sında AVF, % 10,5’unda AVG, % 9,8’inda ise kalıcı kateter uygulandığı belirlenmiştir. Çalışmaya alınan hastalarda ortalama AVF patensi 34.73 ay, ortalama AVG patensi 27.59 ay, ortalama kalıcı kateter patensi ise 8.53 ay olarak belirlendi. Vasküler erişim yolu patensini yaş, vasküler erişim yolu oluşturulmadan önceki santral venöz kataterizasyon öyküsü, vasküler erişim yolunun ilk kullanım zamanı ve operasyon öncesi üst ekstremite arteriyel ve venöz dopler USG incelemesinin etkilediği saptandı. Sonuç: Kalıcı damar yolunun ömrünün uzatılmasında hastanın yaşı, santral venöz kateter öyküsü ve fistül ve greftin olgunlaşma sürecinin beklenmesi önem arz etmektedir. Hemodiyaliz için kalıcı damar yolu planlanan hastada santral venöz kateter uygulamasından kaçınılmalı ve kanüle edilmeden önce AVFAVG’in olgunlaşma süreci beklenmelidir.
MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone
(Taylor and Francis Ltd., 2021) Kara, Sonat Pınar; Özkan, Gülsüm; Yılmaz, A.; Bayrakçı, Nergiz; Güzel, S.; Geyik, E.
Aim: MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone. Method: Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the study. Patients’ demographic data were recorded, and office blood pressure measurement and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed. Blood specimens were collected for miRNA 21, miRNA 155 and aldosterone measurement. MiRNA 21 and miRNA 155 levels in the control and patient groups and their relations with other demographic and biochemical parameters were then subjected to analysis. Results: No difference was determined in miRNA 155 levels between the groups, but miRNA 21 and aldosterone levels were significantly higher in the RH group (p < 0.001 and <0.05, respectively). At correlation analysis, miRNA 21 exhibited positive correlation with aldosterone, age, office SBP, 24-h ABPM all-day SBP. A 9.6 copy/uL level for miRNA 21 predicted presence or absence of RH with 95% sensitivity and 71% specificity (AUC:0.823, 95% CI (0.72–0.92). Conclusion: The study results revealed significantly higher miRNA 21 and aldosterone in RH patients than in healthy individuals and newly diagnosed hypertensives. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Namık Kemal Üniversitesi Tıp Fakültesi Öğrenci Ve Çalışanlarında Hipertensiyon Farkındalığı
(Namık Kemal Üniversitesi, 2017) Yavuz, Enes; Girici, Merve; Özden, Furkan; Baran, Şeyma; Duran, Hüsna; Yılmaz, Efekan; Serin, Diyap; Özkan, Gülsüm
Hipertansiyon (HT) tüm dünyada ve Türkiye’de yaygın görülen bir hastalıktır. Türkiye’de HT prevelansı % 31.8’dir. HT aynı zamanda önemli hayati organları etkileyen, önemli morbidite ve mortaliteye yol açan, maliyeti yüksek bir hastalıktır. HT’un belki de en önemli özelliği semptomlarının silik olması nedeniyle farkındalığının düşük olmasıdır. Türk Hipertansiyon ve Böbrek Hastalıkları derneği tarafından yapılan HT prevelans çalışmasında, Türkiye’de HT farkındalığı %40 olarak saptanırken, Hipertansif bireylerin % 31’inin antihipertansif tedavi aldığı ve % 8’inin kan basıncının (KB) kontrol altında olduğu saptanmıştır. Biz çalışmamızda Tıp fakültesi öğrencileri ve çalışanları arasındaki HT farkındalığını değerlendirmeyi amaçladık.
Prediyaliz Hastalarında Risk Faktörlerinin ve Farkındalık Düzeylerinin Belirlenmesi
(2019) Özpancar, Nurhan; Malkoç, Filiz; Özkan, Gülsüm
ÖZAmaç: Bu çalışma prediyaliz hastalarında risk faktörlerinin ve farkındalık düzeylerinin belirlenmesi amacıyla yapılmıştır.Gereç ve Yöntem: Tanımlayıcı ve kesitsel olarak planlanan bu araştırma, 01.04.2017-01.07.2017 tarihleri arasında, bir üniversite hastanesinin nefroloji polikliniğinde yürütülmüştür. Araştırmanın evrenini, belirtilen tarihler arasında polikliniğe başvuran kronik böbrek hastalığı tanısı almış 185 hasta, örneklemini ise iletişim sorunu olmayan, anket sorularını cevaplamayı kabul eden 155 hasta oluşturmuştur. Veriler araştırmacılar tarafından hazırlanan, hastaların sosyodemografik ve hastalığına ilişkin özelliklerini sorgulayan 34 sorudan oluşanbilgi formu ile toplandı. Verilerin değerlendirilmesinde, frekans, yüzdelik ve ki kare testi uygulandı. p<0,05 anlamlı kabul edildi.Bulgular: Yaş ortalaması 64,96±12,83 olan hastaların, %56,8’i erkek, %64,5’i ilköğretim mezunu ve %11,6’sı sigara kullanmaktadır. Çoğunluğu (%38,7) fazla kilolu/obez, %40,0’ı evre 2 böbrek yetmezliği tanısı ile izlenmektedir. Başvuru nedeni olarak %50,3’ü diğer polikliniklerden yönlendirildiğini ve %15,5’i şikayet olarak yorgunluk ve ağrı yaşadığını ifade etmiştir. Hastaların %56,1’inin hastalıklarının nedenini bilmediği, çoğunluğunun (%92,9) ilaçlarını düzenli kullandıkları ve %93,5’inin reçetesiz ilaç kullanmadıkları bulunmuştur. Hastaların %70,3’ü diyetleri hakkında bilgi sahibi olduklarını, %43,2’si az tuzlu beslendiğini belirtmiştir. Sistolik Kan Basıncı ortalaması 139,09±25,61, Diyastolik Kan Basıncı ortalaması ise 82,06±14,21’dir. Hastaların kronik böbrek hastalığı evresi ile; cinsiyet, eğitim durumu, beden kitle indeksi ve sigara kullanma durumu arasındaki farkistatistiksel olarak anlamlı (p<0,05) bulunmuştur.Sonuç: Kronik böbrek hastalığı risk faktörleri arasında yer alan erkek cinsiyet, başka bir komorbid hastalık, düşük eğitim düzeyi, fazla kilolu/obez olma durumu araştırmamızda da çoğunluğu oluşturduğu ve hastaların farkındalıklarının düşük olduğu sonucuna ulaşılmıştır.
Procollagen C-proteinase enhancer-1 and renal failure in multiple myeloma
(Springer, 2022) Bayrakçı, Nergiz; Özkan, Gülsüm; Akpınar, Seval; Ediz, Bartu; Yılmaz, Ahsen; Çelikkol, Aliye
Background Renal involvement is present in approximately 50% of multiple myeloma (MM) cases and is associated with a poor prognosis. Procollagen C-Proteinase Enhancer 1 (PCPE-1) is an extracellular matrix glycoprotein that has been shown to increase collagen production by enhancing the activity of Procollagen C-Proteinase (PCP) involved in collagen fibrillogenesis and contribute to the fibrotic process. This study investigates the relationship between PCPE-1 and renal function in myeloma patients. Methods Eighty-one adults, consisting of 61 patients diagnosed with MM and 20 healthy controls, were included in this cross-sectional study. The MM patients with renal injury (RI) were classified as MM-RI( +) and those with no RI as MM-RI(-). Results The median serum PCPE-1 level was 10.7 (5.0-39.4) ng/mL for the entire study population, 9.9 (5.0-13.6) ng/mL for the control group, 10.0 (6.4-22.5) ng/mL for the MM-RI(-) group, and 11.4 (8.1-39.4) ng/mL for the MM-RI( +) group. The difference between the control group and MM-RI( +) group was statistically significant (p < 0.013). PCPE-1 levels negatively correlated with estimated glomerular filtration rate (eGFR), serum albumin, and hemoglobin levels but positively correlated with serum creatinine and CRP levels in the entire study population. Among MM patients, only serum phosphorus and beta-2-microglobulin (beta 2M) were positively correlated with PCPE-1. PCPE-1 levels was not affected by other parameters in the entire study population and in the MM group. Conclusions Although serum PCPE-1 was higher in the MM-RI( +) group, it was thought to be associated with low GFR reflecting non-specific kidney injury rather than myeloma-related kidney injury.
Relapse of minimal change disease after inactivated SARS-CoV-2 vaccination: case report
(Springer, 2022) Özkan, Gülsüm; Bayrakçı, Nergiz; Karabağ, Sevil; Güzel, Eda Çelik; Ulusoy, S.
[No Abstract Available]
Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease
(Karger, 2020) Kara, Sonat Pınar; Özkan, Gülsüm; Özkaramanlı Gür, Demet; Emeksiz, Gaye Kübra; Yılmaz, Ahsen; Bayrakçı, Nergiz; Güzel, Savaş
Introduction:Chronic kidney disease (CKD) is a widespread health problem, in which mortality is most frequently due to cardiovascular diseases. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein. MFAP4 is involved in several biological processes, particularly the maintenance of vascular integrity and extracellular matrix remodeling. Our review of the literature revealed no data concerning MFAP4 levels in CKD and its relationship with myocardial functions.Objective:The purpose of this study was therefore to investigate MFAP4 levels in CKD, parameters affecting these, and the relationship with myocardial functions.Materials and Methods:Seventy-nine CKD patients and 30 healthy controls were included in the study. Routine biochemical tests and echocardiography were performed once demographic data had been recorded. Blood specimens were collected for MFAP4 analysis, and the results were subjected to statistical analysis.Results:MFAP4 levels were significantly higher in the patient group than in the control group (p< 0.001). Doppler parameters revealed more frequent LV diastolic impairment in the patient group. Tissue Doppler systolic velocity and global longitudinal strain were significantly impaired, revealing the subclinical LV systolic dysfunction in CKD patients. MFAP4 elevation in the patient group was positively correlated with aortic root (AR), global circumferential strain (GCS), and GCS rate.Conclusion:Our results showed MFAP4 elevation in CKD for the first time in the literature, and that this elevation may be related to GCS and AR dilation. We think that, once supported by further studies, MFAP4 may constitute a marker in the evaluation of myocardial functions in CKD.
Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings
(NLM (Medline), 2021) Bayrakçı, Nergiz; Özkan, Gülsüm; Mutlu, Levent Cem; Erdem, L.; Yıldırım, İlker; Gülen, Dumrul; Çelikkol, Alive
Coronavirus-related disease-2019 (COVID-19)-associated coagulopathy presents predominantly with thrombosis and leads to complications in close association with inflammatory process. Soluble endothelial protein C receptor (sEPCR), which is the soluble form of EPCR, reduces the anticoagulant and anti-inflammatory activity of activated protein C. The purpose of this study is to investigate the relationship between sEPCR and the laboratory parameters and thorax computed tomography (CT) findings in the course of COVID-19. Twenty-five laboratory-confirmed [reverse transcription-quantitative polimerase chain reaction (RT-qPCR) positive] and 24 clinically diagnosed (RT-qPCR negative) COVID-19 patients were enrolled in the study. Blood specimens were collected for sEPCR and haematological and biochemical parameter measurement. Thorax CT was performed to detect COVID-19 findings. These parameters from RT-qPCR positive and negative patients were then compared. Although there was no difference between the groups in terms of symptoms, the time between the onset of symptoms and the admission time was shorter in RT-qPCR positive group (P?=?0.000). sEPCR levels were significantly higher in the RT-qPCR positive group (P?=?0.011). Patients with ground-glass opacity and bilateral involvement on thorax CT have higher serum sEPCR levels (P?=?0.012 and 0.043, respectively). This study has shown for the first time that serum sEPCR levels, which is a member of coagulation cascade and has also been reported to be associated with inflammation, is higher in patients with positive RT-qPCR test and patients with GGO or bilateral involvement on thorax CT regardless of the PCR result. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients
(Hindawi Limited, 2022) Bayrakçı, Nergiz; Özkan, Gülsüm; Kara, Sonat Pınar; Yılmaz, A.; Güzel, Savaş
Background. Hypertension is one of the leading causes of cardiovascular mortality. Although the pathogenetic process involved is not yet fully understood, the disease involves endothelial damage and inflammation. Calprotectin is an inflammatory marker that rises in parallel with disease activity in conditions such as systemic inflammatory diseases, infection, and atherosclerosis. The purpose of this study was to evaluate inflammation through serum calprotectin levels in newly diagnosed primary hypertension patients. Methods. Forty-nine newly diagnosed hypertensive patients and 38 healthy adults were included in the study. Patients' office blood pressure values, biochemical findings, and demographic characteristics were recorded. Serum calprotectin levels were measured using ELISA. Parameters affecting serum calprotectin levels and determinants of hypertension were evaluated. Results. Serum calprotectin levels were 242.8 (72.4-524) ng/mL in the control group and 112.6 (67.4-389.8) ng/mL in the hypertensive patient group, the difference being statistically significant (p=0.001). There was no correlation between serum calprotectin levels and other parameters (blood pressure values, age, gender, serum creatinine, uric acid, and calcium levels) in the hypertensive group. A lower serum calprotectin level was found to be independently related to hypertension (? = -0.009, p=0.005). Serum calprotectin at a cutoff level of 128.6 ng/mL differentiated hypertensives from healthy controls with a sensitivity of 69.4% and specificity of 68.4% (AUC = 0.767). Conclusions. The results of this study were the opposite of our hypothesis that a higher calprotectin level may reflect subclinical endothelial damage in newly diagnosed hypertensive patients. Further comparative studies involving patients at different stages of hypertension may contribute to clarifying the relationship between calprotectin and hypertension. We conclude that molecular studies seem essential for understanding the place of calprotectin in hypertension-associated inflammation, a complex process. © 2022 Nergiz Bayrakci et al.
Serum Soluble Urokinase Plasminogen Activator Receptor Levels in Resistant Hypertension
(2024) Bayrakcı, Nergiz; Özkan, Gülsüm; Kara, Sonat Pınar; Yılmaz, Ahsen; Çelikkol, Aliye
Background: Although the precise pathogenetic mechanisms remain incompletely elucidated, hypertension is character- ized by endothelial damage and inflammation. The soluble urokinase plasminogen activator receptor (suPAR) is an inflam- matory biomarker that increases in parallel with disease activity in conditions such as systemic inflammation, infection, cancer, and atherosclerosis. The objective of this study was to assess inflammation by means of serum suPAR levels in hypertensive patients and those with resistant hypertension. Methods: Eighty-six adults, 29 newly diagnosed hypertensive patients (HT group) and 23 resistant hypertensive patients (RHT group) and 34 healthy controls, were included in this cross-sectional, observational study. Ambulatory blood pressure monitoring results were included in the analysis. Serum suPAR levels were measured using Enzyme-Linked ImmonuSorbent Assay (ELISA). Patients were divided into 2 groups as “high suPAR” and “low suPAR.” Results: The serum suPAR level was lower in the control group than that of the HT and RHT groups (P = .001). Systolic and diastolic blood pressure values were positively correlated with the serum suPAR level (r = 0.254, P = .018; r = 0.239, P = .027, respectively). Being in the high-suPAR group was found to increase the risk of RHT by 19.5 times. Other risk factors for RHT were found to be lower urinary sodium excretion and higher urinary albumin excretion [odds ratio (OR) = 0.98; OR = 1.09, respectively]. Conclusion: In our study, suPAR levels were found associated with RHT. To our best knowledge, this study is the first to evaluate the relationship between serum suPAR levels and RHT.
Soluble endothelial protein C is associated with blood pressure variability and salt consumption but not mean blood pressure in patients with newly diagnosed primary hypertension
(Taylor & Francis Inc, 2019) Özkan, Gülsüm; Kara, Sonat Pınar; Fidan, Çiğdem; Güzel, Savaş; Ulusoy, Şükrü
Background: Hypertension is a widespread disease involving frequent thrombotic complications. Blood pressure variability (BPV) has recently been shown to be associated with end-organ damage and cardiovascular events. However, the pathogenesis of the relation between BPV and cardiovascular events has not yet been explained. Soluble endothelial protein C (sEPCR) exhibits a procoagulant effect by reducing the anticoagulant and anti-inflammatory effects of protein C and activated protein C. The purpose of this study was to evaluate sEPCR levels in hypertensive individuals and the parameters affecting that level, particularly BPV. Methods: Fifty-one newly diagnosed hypertensive subjects and 31 healthy individuals were included in the study. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed after office control, and simultaneous 24-h urine was collected. BPV was calculated with average real variability (ARV) from ABPM data. Blood specimens were collected under appropriate conditions for sEPCR levels and biochemical tests. sEPCR levels were compared between the patient and healthy groups, after which parameters affecting sEPCR elevation in the hypertensive group were evaluated. Results: sEPCR levels were significantly high in the hypertensive group (p < 0.05). At multivariate regression analysis in the hypertensive group, sEPCR was determined to be independently associated with 24-h systolic ARV (beta = 0.572, p < 0.05) and 24-h urine Na (beta = 0.428, p < 0.05). Conclusion: In our study, sEPCR was high in hypertensive individuals, and this elevation was related to ARV and urine Na excretion independently of mean blood pressure.

Yazar "Özkan, Gülsüm" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri