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Öğe Abdominal aorta and its branches: Morphometry - Variations in autopsy cases(TIP ARASTIRMALARI DERNEGI, 2010) Songur, Ahmet; Toktaş, Muhsin; Alkoç, Ozan Alper; Acar, Tolgahan; Uzun, İbrahim; Baş, Orhan; Özen, Oğuz AslanAim: Knowing the morphology of abdominal aorta (AA) and its branches are important as regards to diagnosis and surgical treatment. The aims of this study were to a) make morphometric measurements of AA and its branches, b) to investigate sites of the origins of the branches and their relationships and variations, and c) to compare the results with literature.Method: Ninety-five AA which had been removed in autopsies were measured with caliper morphometrically to determine diameters of branches and distances between branches. Possible variation of the vessels were investigated and photographed.Result: It was found that diameters of celiac trunk (CT), superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) were 6.43±1.59 mm, 7.38±1.67 mm and 3.61±0.72 mm respectively. The distances between CT and aortic bifurcation (AB), CT and SMA, SMA and IMA, IMA and AB were 107.21±11.46 mm, 14.34±2.67 mm, 57.76±8.04 mm, 35.20±7.41 mm respectively. Numerous variations were observed during the study. These variations involved inferior phrenic artery (single trunk arising from CT, 4.2%), renal artery-RA (duplicated right RA 9.5%, duplicated left RA 4.2%, bilaterally duplicated 3.1%, %16.8 total multiple RA), gonadal arteries-GA (single GA, 1%), lumbar arteries-LA (3 pairs of LA 11.5%, 3rd or 4th LA arising as single trunk 3.1%) and median sacral artery (agenesis 2.1%). Conclusion: Knowledge of morphology of AA and its branches is important in regards to the diagnosis, surgical treatment and endovascular interventions of these vessels. We think our study will contribute to the medical education and clinical medicine in our country.Öğe Absence of Middle Hepatic Vein Combined with Retro-Aortic Left Renal Vein: a Very Rare Case Report(Galenos Publ House, 2012) Turamanlar, Ozan; Kırpıko, Oğuz; Özen, Oğuz Aslan; Değirmenci, Bumin; Akçer, Sezer; Uygur, RamazanThe hepatic and renal veins drain into the inferior vena cava. The upper group of hepatic veins consists of three veins which extend to the posterior face of the liver to join the inferior cava. The left renal vein passes anterior to the aorta just below the origin of the superior mesenteric artery. We detected a variation in the hepatic and renal veins in a multislice CT angiogram of a nine-year-old male patient in the Radiology Department of Afyon Kocatepe University Medical School. The upper group hepatic veins normally drains into the inferior vena cava as three separate trunks, namely the right, left and middle. In our case, we found that only the right and left hepatic veins existed and the middle hepatic vein was absent. Furthermore, the left renal vein, which normally passes anterior to the abdominal aorta, was retro-aortic. Left renal vein variations are of great importance in planning retroperitoneal surgery and vascular interventions. Knowledge of a patient's hepatic vein and renovascular anatomy and determining their variations and anomalies are of critical importance to abdominal operations, transplantations and preoperative evaluation of endovascular interventions.Öğe Anatomi Eğitimi Hakkında Öğrenci Görüşlerinin Değerlendirilmesi(Namık Kemal Üniversitesi, Tıp Fakültesi, 2013) Uygur, Ramazan; Çağlar, Veli; Topçu, Birol; Aktaş, Sadiye; Özen, Oğuz AslanAmaç Çalışmamızda Namık Kemal Üniversitesi Tıp Fakültesi’nde eğitim gören ikinci sınıf öğrencilerinin Anatomi Anabilim Dalı tarafından verilen anatomi eğitiminin mevcut durumu hakkındaki görüşlerinin yapılan anket yardımıyla değerlendirilmesi amaçlandı. Materyal ve Metot Çalışmamıza 2012-2013 eğitim-öğretim yılında Namık Kemal Üniversitesi Tıp Fakültesi ikinci sınıfta anatomi dersini alan 79 öğrenci dahil edildi. Öğrencilerin almış oldukları anatomi eğitimi hakkındaki görüşleri anket yöntemiyle belirlendi. Bulgular Çalışmamızda öğrencilerin tıp fakültelerini isteyerek tercih ettikleri ve anatomi eğitiminden memnun oldukları görüldü. Öğrencilerin sınıf mevcudunun az olmasını, uygulama dersi çalışma gruplarının daha az sayıda kişiden oluşmasını, kadavra ve maket sayısının arttırılmasını, uygulama ders saatinin arttırılmasını istedikleri belirlendi. Öğrencilerin anatomi sınavlarının sayı ve formatını uygun buldukları, ders içerisinde verilen klinik anatomi bilgilerinden memnun oldukları saptandı. Anatomi dersinde başarılı olan öğrencilerin derse daha ilgili, ders çalışmayı seven, derse devamlılık gösteren kişiler oldukları ve öğrendikleri anatomi bilgilerini kullanabildikleri tespit edildi. Sonuç Anatomi eğitiminden daha fazla verim alabilmek için, öğrencilerin anatomi dersi hakkındaki görüşlerinin alınmasının anatomi eğitimine katkı sağlayabileceği ve yol gösterici nitelikte olabileceği belirlendi.Öğe Answer to the Letter to the Editor concerning 'Effects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats'(Wiley-Blackwell, 2015) Uygur, Ramazan; Yağmurca, Murat; Alkoç, Ozan Alper; Genç, Abdurrahman; Songur, Ahmet; Üçok, Kağan; Özen, Oğuz Aslan[No Abstract Available]Öğe Avokado/soya fasülyesinin sabunlaşmayan ekstresi verilen köpeklerin dizlerinde osteokondral defekt iyileşmesi: Bir karşılaştırmalı morfometrik analiz(2011) Altınel, Levent; Şahin, Önder; Köse, Kamil Çağrı; Baş, Orhan; Özen, Oğuz Aslan; Sarıtaş, Z. Kadir; Pamuk, KamuranAmaç: Bu çalışmada avocado/soya fasülyesinin sabunlaşmayan ekstresinin (ASE) köpek osteokondral defekt modelinde iyileşmeye etkisi belirlendi. Gereç ve yöntemler: On dört köpek çalışmaya alındı ve rastgele olarak iki gruba ayrıldı. Diz ekleminin troklear oluğunun lateral yüzünde iki adet osteokondral defekt oluşturuldu. Tedavi grubuna (grup 1; n=7) her üç günde bir 300 mg’lik ASE kapsülleri, kontrol grubuna (grup 2; n=7) ise normal diyet verildi. On beş hafta sonrasında ötenazi yapılana kadar hayvanlar kafesler içinde serbest gezinmeye bırakıldı. Dizler açılarak defektli troklear oluklar patolojik inceleme için çıkarıldı. Rejenere doku miktarı görüntü analiz yöntemiyle kantitatif olarak, doku içeriği ise Safranin-O ve Masson trikrom histokimyasal boyamaları ile semikantitatif olarak değerlendirildi. Transforme edici büyüme faktörü-beta (TGF-b) artışı, immünhistokimyasal boyama yöntemiyle semikantitatif olarak değerlendirildi. Bulgular: Morfometrik analiz sonucunda grup 1’de anlamlı ölçüde daha fazla immatür iyileşme dokusu saptandı (p<0.002). Grup 1’de rejenere dokuda hem kollajen hem de kondral doku içeriği anlamlı ölçüde artmıştı (p<0.002). Grup 2’ye kıyasla grup 1’de kıkırdak dokusunda TGF-b immün boyanma reaksiyonu çok daha belirgindi. Sonuç: Avocado/soya fasülyesinin sabunlaşmayan ekstresi ile yapılan tedavi, köpek dizinde osteokondral defekt iyileşmesini uyarmakta ve muhtemelen dokuda TGF-b’yı artırarak bu etkiyi sağlamaktadır.Öğe Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats(Sage Publications Ltd, 2014) Uygur, Ramazan; Aktaş, Cevat; Tülübaş, Feti; Alpsoy, Şeref; Topçu, Birol; Özen, Oğuz AslanThe aim of this study was to investigate the protective effects of fish omega-3 (n-3) fatty acids on doxorubicin (DOX)-induced acute cardiotoxicity. A total of 24 rats were divided into three groups: control, DOX-treated, and DOX treated with fish n-3 fatty acids. Control group received 0.4 ml/kg/day of saline intragastrically. The rats in the fish n-3 fatty acid-pretreated group were given 400 mg/kg/day fish n-3 fatty acids for 30 days by intragastric intubation. To induce acute cardiotoxicity, DOX (30 mg/kg) was injected intraperitoneally by a single dose and the rats were killed after 48 h. DOX treatment caused severe damage in heart tissues. Disorganization of myocardial muscle fibers, myofibrillar loss, and cardiotoxic myocardial fibers with cytoplasmic vacuoles were seen. Fish n-3 fatty acid-treated rats showed an improved histological appearance in the DOX-treated group. Our data indicate a significant reduction in the activity of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling in cardiomyocytes of the DOX-treated group with fish n-3 fatty acids therapy. The DOX-treated with fish n-3 fatty acids group showed a significant decrease in malondialdehyde levels, and an increase in superoxide dismutase and glutathione peroxidase activities in comparison with the DOX-treated group. This study showed that fish n-3 fatty acids may be a suitable cardioprotector against acute toxic effects of DOX.Öğe Çoklu Patolojili meningoensefalosel olgusu(2013) Turamanlar, Ozan; Kırpıko, Oğuz; Özen, Oğuz Aslan; Sancaktar, MuratMeningoensefalosel, kalvaryumdaki bir defektten, kraniyal içeriklerin, kafatasının normal sınırlarının ötesine geçip çıkması olarak tanımlanabilir. Sağ maksiller bölgede şişlik şikayeti olan altı günlük bir erkek bebeğin çekilen kraniyal BT incelemesinde sağ temporal meningoensefalosele ait görünüm vardı. Ayrıca korpus kallosum disgenezisini dü- şündüren görünüm de bulunmaktaydı. Olgumuzdaki gibi bir anomali literatürde oldukça az rastlanan bir durumdur. Meningoensefalosel ile diğer konjenital beyin lezyonlarının birbirinden ayrımı, tedavi ve prognozlarının tamamen farklı olması nedeniyle büyük önem taşımaktadır.Öğe Complex variation of median nerve: A case report(2013) Özen, Oğuz Aslan; Songur, Ahmet; Gönül, Yücel; Uygur, RamazanDuring routine dissections we saw complex variation of median nerve in the right arm of an adult male cadaver. Lateral cord continued as lateral root of median nerve without giving off musculocutaneous nerve and it formed median nerve joining with medial root of median nerve which arises from medial cord. There was a communicating accessory branch 2.5 cm long running obliquely between the cords which formed the median nerve. Coracobrachialis muscle was innervated by a thin branch arising from lateral cord. Median nerve given two branches at a point 9 cm distal to its formation. First branch supplied to biceps brachii, the second branch continued as brachial muscle's nerve and lateral antebrachial cutaneous nerve. Main trunk passed through the cubital fossa and ran along the forearm following the normal course of median nerve. We think it is important that clinicians performing surgical procedures or nerve blocks in this region should consider this variation in order to avoid failures and complications.Öğe Determination of normal splenic volume in relation to age, gender and body habitus: a stereological study on computed tomography(Via Medica, 2014) Çağlar, Veli; Alkoç, Ozan Alper; Uygur, Ramazan; Serdaroglu, O.; Özen, Oğuz AslanBackground: The aim of this study is to assess and document the dimensions of the normal spleen measured on computed tomography (CT) images with the normal splenic volume measured by Cavalieri principle on CT images and thereby serve as a baseline for comparison in cases of splenomegaly using abdominal CT. To investigate the relationship between these changes and body mass index, gender, abdominal diameters. Materials and methods: We retrospectively reviewed abdominal CT examinations of 212 adults between the ages of 20 and 88 years. There were seven groups of patients. The spleen volume (SV) measurements using abdominal CT images of each patient on the Image Information Systems were performed with Cavalieri principle. Results: The mean SV and splenic length (SL), width (SW), and thickness (ST) for the total study population of 212 patients was 198 +/- 88 cm(3), 9.96 +/- 2.1 cm, 8.87 +/- +/- 1.6 cm and 4.58 +/- 0.8 cm, respectively. There was a strong correlation between SV and ST (r = 0.752, p < 0.001), SL (r = 0.735, p < 0.001), SW (r = 0.681, p < 0.001) mean values of total study population. Comparison between mean splenic dimension parameters for males and females showed a statistically significant difference (p = 0.032 for SV, p = 0.04 for ST) but no statistically significant difference with SL and SW. Also there was a positive correlation between SV and body height, sagittal abdominal diameter and transvers abdominal diameter in mean of total groups and female groups, there was no correlation in males. Conclusions: The normal reference ranges for SV and size given in this study can serve as a standard to judge whether splenomegaly is present in patients.Öğe Determining the Morphometry and Variations of the Confluens Sinuum and Related Structures Via a Silicone Painting Technique on Autopsy Patients(Lippincott Williams & Wilkins, 2014) Coşar, Murat; Seker, Askin; Ceylan, Davut; Tatarli, Necati; Şahin, Fevzi; Tokmak, Mehmet; Özen, Oğuz AslanIn this study, we aimed to investigate the morphometric and morphologic structures of the confluens sinuum (CS) and related structures with a silicone painting technique. We studied 30 cadavers. Twelve of them were washed with alcohol and filled with a silicone painting technique via the vena jugularis interna, internal carotid artery, and vertebral artery. The other 18 were autopsied postmortem. The CS and related structures were dissected under microscope. Their anatomy was investigated, and variations were noted. The diameters of the sinus sagittalis superior (SSS), CS, occipital sinus (OS), sinus rectus (SR), and bilateral transverse sinus (TS), and the angle between SSS and SR were measured. The mean diameters were 11.7 mm for SSS, 22.3 mm for CS, 5.25 mm for OS, 7.5 mm for SR, and 9.7 (right) and 9.1 mm (left) for TS. The angle between the SR and SSS was 58 degrees. There was no difference in the bilateral venous structures that drained to the SSS and TS. There was an extra drainage to the CS from the left side in 4 cases. The right TS was located superiorly in 7 cases compared with the left TS, and this process was correlated with the type of CS. A septum in the SSS was detected in 2 cases. In addition, we encountered an OS in 80% of the cases. We conclude that the septum inside the CS affects the dominancy of the TS, the angle between the SSS and SR, and the other venous variations.Öğe Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats(Humana Press Inc, 2011) Özen, Oğuz Aslan; Kuş, İlter; Bakırdere, Sezgin; Sarsılmaz, Mustafa; Yaman, MehmetIn the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation. After inhalation procedure, concentration of copper, zinc and iron were determined in liver and kidney tissues of rats using atomic absorption spectrophotometer. In addition, concentrations of Cu, Zn and Fe changed by the effect of formaldehyde in subacute and subchronic groups.Öğe Effects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats(Wiley, 2014) Uygur, Ramazan; Yağmurca, Murat; Alkoç, Ozan Alper; Genç, Abdurrahman; Songur, Ahmet; Üçok, Kağan; Özen, Oğuz AslanThe aim of this study was to investigate the effects of quercetin and fish n-3 fatty acids on the changes in testis induced by ethanol. Forty-five rats divided into five groups, control, ethanol, ethanol+quercetin, ethanol+fish n-3 fatty acids and ethanol+quercetin+fish n-3 fatty acids. Atthe end of 8weeks, all the rats were sacrificed. Degenerative changes in histopathological analyses, the decreased body weight gain and seminiferous tubule diameters in ethanol group have been observed. TUNEL assay also showed an increase in apoptotic cell number. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase (XO) and testosterone levels were decreased as well as the levels of malondialdehyde (MDA) and nitric oxide (NO) were increased in ethanol group. Histopathological changes caused by ethanol have been improved by quercetin and fish n-3 fatty acids. It was also found that protection was provided by increasing SOD, CAT and GSH-Px activities in groups administered quercetin, fish n-3 fatty acids and quercetin+fish n-3 fatty acids, and by decreasing the levels of MDA and NO in groups administered both quercetin and fish n-3 fatty acids together. These results suggest that quercetin and fish n-3 fatty acids are beneficial agents to reduce testicular injury induced by ethanol except for testosterone levels.Öğe Hemiplejik Serebral Palsili Çocuklarda Gövde Antropometrik Ölçümlerinin Değerlendirilmesi(Namık Kemal Üniversitesi, Tıp Fakültesi, 2013) Uygur, Ramazan; Özen, Oğuz Aslan; Baş, Orhan; Uygur, Emine; Songur, AhmetAmaç Çalışmamızda hemiplejik serebral palsili (HSP) çocuklarda beslenme ve solunum kapasitesi hakkında bilgi veren gövde antropometrik ölçümlerinin incelenmesi amaçlandı. Gereç ve Yöntem Çalışmamız-da 5-12 yaş grubundan 32 HSP’li çocuk ile 40 normal çocuğun gövde antropometrik ölçümleri yapıldı. Bulgular HSP’li çocukların kilo, boy uzunluğu, vücut kitle indeksi (VKİ), kulaç uzunluğu, omuz çevresi, göğüs (aksilla) çevresi, bel çevresi, abdomen çevresi, kalça çevresi, toraks genişliği, toraks derinliği, omuz genişliği, biakromial genişlik, biiliak genişlik ve bitrokanterik genişlik değerlerinin normal çocuklara göre istatistiksel olarak anlamlı derecede düşük olduğu gözlendi. Göğüs (ksifoid ve subkostal) çevresi değerlerinde ise HSP’li çocuklar ile normal çocuklar arasında anlamlı bir fark gözlenmedi. HSP’li çocuklarda beslenme ve solunum kapasitesi hakkında bilgi veren gövde antropometrik ölçümleri normal çocuklara göre daha düşük değere sahiptir. Sonuç HSP’li çocuklar ortaya çıkan fonksiyonel yetersizlik sonucu yaşıtlarına oranla geri kalmakta ve yaşam kaliteleri düşmektedir.Öğe Hemiplejik serebral palsili çocukların baş ve boyun gelişiminin antropometrik ölçümler kullanılarak değerlendirilmesi(2014) Uygur, Ramazan; Özen, Oğuz Aslan; Baş, Orhan; Çağlar, Veli; Songur, AhmetAmaç: Serebral palsi gelişimini tamamlamamış beyin dokusunun ilerleyici olmayan bir hastalığının sebep olduğu, kalıcı ancak değişime uğrayabilen hareket ve postür bozukluğunun görüldüğü nörogelişimsel bir yetersizliktir. Çalışmamızda hemiplejik serebral palsi (HSP) ele alınarak,antropometrik ölçümler aracılığıyla baş ve boyun gelişimine olan etkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: HSPli çocuklar ile normal çocukların baş ve boyun antropometrik ölçümleri yapılarak karşılaştırıldı. Bulgular: HSPli çocuklara ait antropometrik ölçümlerden baş çevresi 49,1±2,4 cm, boyun çevresi 26,8±2,3 cm, baş genişliği 13,8±0,8 cm, baş uzunluğu 15,8±1 cm, yüz yüksek- liği 11±1 cm, yüz genişliği 7,8±1 cm, göz bebekleri arası uzaklık 5,4±0,6 cm ve boyun genişliği 7,9±0,8 cm olarak bulundu. Normal çocukların baş çevresi 51,1±1,6 cm, boyun çevresi 27,2±2 cm, baş genişliği 14,6±0,6 cm, baş uzunluğu 16,1±0,7 cm, yüz yüksekliği 11,2±0,6 cm, yüz genişliği 8,9±0,6 cm, göz bebekleri arası uzaklık 5,5±0,4 cm ve boyun genişliği 8,6±0,7 cm olarak ölçüldü. Normal çocukların baş çevresi, baş genişliği, yüz genişliği ve boyun genişliği değerleri HSPli çocukların değerlerine göre istatistiksel olarak anlamlı derecede yüksekti.Sonuç: Sonuç olarak, HSPli çocukların baş antropometrik ölçümlerinin düşük olmasını beyin gelişiminin nörodejenerasyona bağlı olarak az olmasına ve boyun genişliğinin düşük olmasını da beslenme bozukluklarına bağlı olduğunu düşünmekteyiz.Öğe Hemiplejik serebral palsili çocukların üst ekstremitelerinin sağlam tarafı da gelişim geriliği gösterir(2013) Uygur, Ramazan; Özen, Oğuz Aslan; Baş, Orhan; Gönül, Yücel; Songur, AhmetAmaç: Çalışmamızda çocuklarda hemiplejik serebral palsi'nin (HSP) neden olduğu üst ekstremite gelişim geriliğinin antropometrik yöntemlerle incelenmesi amaçlandı. Gereç ve yöntem: Çalışmamızda Etik Kurul onayı alınarak 5-12 yaşlarındaki 32 HSP'li çocuk ile 40 normal çocuğun üst ekstremiteleri antropometrik set ile ölçülerek karşılaştırıldı. Bulgular: HSP'li çocukların sağlam taraf omuz eklemi, kol, dirsek eklemi, ön kol ve el bilek eklemi çevresi; üst ekstremite, kol, ön kol, el ve el ayası uzunluğu; dirsek eklemi, el bilek eklemi ve el genişliği değerleri HSP'li çocukların plejik tarafına göre anlamlı derecede fazlaydı. Normal çocukların omuz eklemi, kol, dirsek eklemi, ön kol ve el bilek eklemi çevresi; üst ekstremite, kol, ön kol, el ve el ayası uzunluğu; dirsek eklemi, el bilek eklemi ve el genişliği değerleri HSP'li çocukların plejik taraf ölçümlerine göre anlamlı derecede yüksekti. Normal çocukların dirsek eklemi ve ön kol çevresi; el ve el ayası uzunluğu; dirsek eklemi, el bilek eklemi ve el (metakarpallerden) genişliği değerleri HSP'li çocukların sağlam tarafına göre anlamlı derecede yüksekti. Sonuç: Antropometrik ölçümler HSP'li çocukların plejik taraf üst ekstremitelerinin sağlam tarafa göre, normal çocuklarla karşılaştırdığımızda ise hem plejik hem de sağlam taraflarının daha az geliştiğini göstermektedir. HSP'li çocukların az gelişmiş plejik taraflarını kullanamamaları günlük yaşam aktivitelerini de kısıtlayarak sağlam tarafta da kas ve kemik gelişim geriliğine sebep olmaktadır. Erken teşhis ve rehabilitasyon ile bu fark azaltılabilirÖğe Modern anatominin kurucularından Hasan Mazhar Paşa(2012) Turamanlar, Ozan; Özen, Oğuz Aslan; Akçer, Sezer; Toktaş, MuhsinHasan Mazhar Paşa Türkiyede modern anatominin kurul- masında söz sahibi olan kişidir. O ve bir grup arkadaşı ile birlikte ülkemizde Türkçe tıp eğitimini başlattılar. Mazhar Paşa birçok tıp teriminin Türkçe karşılıklarını bulup yerleştirilmesinde, özellikle anatomi terimlerinin birçoğunun bulunup kullanılmasında önemli bir hizmet verdi. Aynı zamanda yüzlerce doktor yetiştirdi. Bunlar arasında Prof. Dr. F. Nafiz Uzluk ve Ord. Prof. Dr. Zeki Zeren de bulunmaktadır. Zeki Zeren Onun için Erdem ve fazilet sahibi 41 yıl öğretim üyeliği yapmış hocaların hocasıdır. der.Öğe Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats(Sage Publications Inc, 2016) Ünsal, Cüneyt; Oran, Mustafa; Albayrak, Yakup; Aktaş, Cevat; Erboğa, Mustafa; Topçu, Birol; Özen, Oğuz Aslan; Ateş, ÖzkanThe goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer's disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase in the frontal cortex tissue. The histopathological studies in the brain of rats also supported that ebselen markedly reduced the ICV-STZ-induced histopathological changes and well preserved the normal histological architecture of the frontal cortex tissue. The number of apoptotic neurons was increased in frontal cortex tissue after ICV-STZ administration. Treatment of ebselen markedly reduced the number of degenerating apoptotic neurons. The study demonstrates the effectiveness of ebselen, as a powerful antioxidant, in preventing the oxidative damage and morphological changes caused by ICV-STZ in rats. Thus, ebselen may have a therapeutic value for the treatment of AD.Öğe Planimetry investigation of the corpus callosum in temporal lobe epilepsy patients(Riyadh Armed Forces Hospital, 2016) Çağlar, Veli; Alp, Selen İlhan; Demir, Berrin T.; Şener, Ümit; Özen, Oğuz Aslan; Alp, RecepObjective: To evaluate the effects of temporal lobe epilepsy (TLE) on corpus callosum (CC) morphometry in patients with TLE. Methods: This retrospective study was conducted at the Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey between November 2010 and December 2013. The epileptic syndrome diagnosis was based on International League Against Epilepsy criteria, and this study was conducted on the MRIs of 25 epilepsy patients and 25 control subjects. We classified the patients according to their duration of epilepsy: < 10 and >= 10 years. The projection area length (PAL) of the CC was also estimated. Total brain volumes (TBV) were measured on CT images. Results: The mean values of TBV for patients with TLE and the control group were not statistically different, but the CC PAL values were statistically different. The mean CC PAL values of under and over 25 years of age in patients with TLE were statistically different. The mean values of TBV of under and over 10 years duration of TLE were small statistically, but the CC PAL values were statistically different. Conclusion: The results indicate a clear influence of TLE on the structure of the CC rather than TBV.Öğe Protective Effect of Alpha Lipoic Acid on Rat Sciatic Nerve Ischemia Reperfusion Damage(Galenos Publ House, 2015) Turamanlar, Ozan; Özen, Oğuz Aslan; Songur, Ahmet; Yağmurca, Murat; Akçer, Sezer; Mollaoğlu, Hakan; Aktaş, CevatBackground: Alpha lipoic acid is a potent antioxidant that plays numerous roles in human health. This study examined the effect of ALA on rat sciatic nerve ischemia reperfusion damage. Aims: Protective effect of alpha lipoic acid (ALA) on sciatic nerve following ischemia-reperfusion in rats was investigated by using light microscopy and biochemical methods. Provided that the protective effect of ALA on sciatic nerve is proven, we think the damage to the sciatic nerve that has already occurred or might occur in patients for various reasons maybe prevented or stopped by giving ALA in convenient doses. Study Design: Animal experiment. Methods: Forty-two adult male Sprague-Dawley rats (250-300 grams) were used in this study. Rats were randomly divided into six groups including one control (Group 1), one sham (Group 2), two ischemia-reperfusion (Groups 3 and 4) and two treatment groups (Groups5 and 6). Doses of 60 and 100 mg/kg ALA were given (Group 5 and 6) intra peritoneally twice, 1 and 24 hours before the ischemia to each treatment group. Ischemia was carried out the abdominal aorta starting from the distal part of the renal vein for two hours followed by reperfusion for three hours. In immunohistochemical methods, fibronectin immunoreactivity was analyzed. For biochemical analyses, the tissues were taken in eppendorf microtubes and superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) enzyme activities as well as malondialdehyde (MDA) and nitricoxide (NO) levels were measured. Results: Fibronectin was observed to have increased significantly in the ischemia group; on the other hand, it was observed to have decreased in parallel to the doses in the ALA groups. Biochemical studies showed that SOD and GSHPx declined with ischemia-reperfusion, but the activities of these enzymes were increased in the treatment groups in parallel with the dose. It was found that increased MDA levels with ischemia-reperfusion were decreased in parallel with ALA dose. There were no statistically significant changes in NO. Conclusion: Increased fibronectin observed after ischemia/reperfusion of rat sciatic nerve is reduced after the administration of ALA. This indicates that the function of fibronectin, to reconnect cut nerve segments and regenerate nerves, is more prominent than its function in tissue healing after ischemia. ALA administered before ischemia decreases MDA and increases SOD and GSHPx. We think that ALA may protect against the pathological changes in ischemic nerve and may be used to devise more efficient treatments.Öğe Protective effects of fish omega-3 fatty acids on doxorubicin-induced testicular apoptosis and oxidative damage in rats(Wiley-Blackwell, 2014) Uygur, Ramazan; Aktaş, Cevat; Tülübaş, Feti; Uygur, Emine; Kanter, Mehmet; Erboğa, Mustafa; Özen, Oğuz AslanThe aim of this study was to examine the protective effects of fish omega-3 (n-3) fatty acids on acute doxorubicin (DOX)-induced testicular apoptosis and oxidative damage. 24 male rats were divided into three groups: control, DOX-treated and DOX+fish n-3 fatty acids. Fish n-3 fatty acids (400 mg kg(-1)) were given for 30 days by intragastric gavage. The rats received a single intraperitoneal injection of DOX (30 mg kg(-1)) and were sacrificed after 48 h. The DOX+fish n-3 fatty acids group showed a decrease in malondialdehyde levels and increased activities of superoxide dismutase and glutathione peroxidase in comparison with the DOX-treated group. Acute DOX treatment caused severe damage such as disorganisation and separation of germ cells. The fish n-3 fatty acids-pretreated rats showed an improved histological appearance in the DOX-treated group. Our data indicate a reduction in the activity of terminal deoxynucleotidyl transferase mediated dUTP nick end labelling; there was a rise in the expression of proliferating cell nuclear antigen in testis tissues of the DOX+fish n-3 fatty acids group compared with DOX-treated group. These data suggested that fish n-3 fatty acids pre-treatment may be beneficial for spermatogenesis following acute DOX-induced testicular damage by decreasing germ cell apoptosis and oxidative stress.
