Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

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dc.authorid0000-0001-6140-5181
dc.authorscopusid57216014831
dc.authorscopusid57205400626
dc.authorscopusid8416588900
dc.authorscopusid36023238400
dc.authorscopusid55915823300
dc.authorscopusid24436194200
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidYazici, Cenk Murat/AAA-4330-2020
dc.contributor.authorKurt, Ömer
dc.contributor.authorGevher, Fethullah
dc.contributor.authorYazıcı, Cenk Murat
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorDoğru, Mucahit
dc.contributor.authorAktaş, Cevat
dc.date.accessioned2022-05-11T14:10:07Z
dc.date.available2022-05-11T14:10:07Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractUrethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p< 0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p= 0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p= 0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.
dc.identifier.doi10.1590/S1677-5538.IBJU.2016.0191
dc.identifier.endpage945
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue5en_US
dc.identifier.pmid28537690
dc.identifier.scopus2-s2.0-85033381794
dc.identifier.scopusqualityQ2
dc.identifier.startpage939
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2016.0191
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5293
dc.identifier.volume43
dc.identifier.wosWOS:000417397100021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKurt, Ömer
dc.institutionauthorYazıcı, Cenk Murat
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorDoğru, Mucahit
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndoscopy
dc.subjectMitomycin
dc.subjectTriamcinolone
dc.subjectUrethral Stricture
dc.subjectInternal Urethrotomy
dc.subjectSteroid Injection
dc.subjectRat Model
dc.subjectRecurrence
dc.subjectHalofuginone
dc.subjectManagement
dc.subjectInhibitor
dc.subjectEtiology
dc.subjectRabbits
dc.titleEffect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures
dc.typeArticle

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