Investigation of the Relationship Between Genome Wide Association Studies-derived Polymorphisms and Differentiated Thyroid Cancer Risk in a Turkish Population

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dc.authorscopusid14037106700
dc.authorscopusid54887131700
dc.authorscopusid56735615100
dc.authorscopusid24598133700
dc.authorscopusid57159874200
dc.authorscopusid6506542810
dc.authorscopusid6603267445
dc.contributor.authorDemir, Selma
dc.contributor.authorGürkan, Hakan
dc.contributor.authorÇelik, Mehmet
dc.contributor.authorSezer, Atakan
dc.contributor.authorEker, Damla
dc.contributor.authorGüldiken, Sibel
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorTozkır, Hilmi
dc.date.accessioned2022-05-11T14:41:14Z
dc.date.available2022-05-11T14:41:14Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractBackground: Thyroid cancer is the most common malignancy of endocrine system. Genome Wide Association Studies (GWAS) revealed a number of common variants associated with thyroid cancer risk. In this study, we aimed to investigate the association of these known variants with thyroid cancer risk in a Turkish population living in Trakya region. Methods: The study included 97 cases of differentiated thyroid cancer and 379 healthy controls. Real-Time Polymerase Chain Reaction (RT-PCR) method was used for the genotyping of rs965513, rs944289, rs966423 rs2439302 polymorphisms. Results: There was no statistically significant difference between patients and controls in terms of SNP genotype and allele frequencies. The distribution of cumulative genetic risk scores between patients and controls was also not significantly different. In the multiple logistic regression analysis (MLR), it was observed that the relationship of rs2439302 polymorphism GG genotype with thyroid cancer risk has a trend to be significant ((p = 0.067, 95%CI: 2.947 (0.928-9.357)). Conclusion: We suggest that the confirmation of the association of common variants with thyroid cancer in different populations will contribute to make a consensus on global risk alleles. The marginal significance of the association of rs2439302 with thyroid carcinoma risk shown in our study supports the need for functional studies on the role of this polymorphism in thyroid carcinoma.
dc.description.sponsorshipTrakya University Scientific Research Projects UnitTrakya University [TuBAP 2016/132]
dc.description.sponsorshipThis study has been financially supported by the Trakya University Scientific Research Projects Unit (TuBAP 2016/132) .
dc.identifier.doi10.12996/gmj.2021.123
dc.identifier.endpage553
dc.identifier.issn2147-2092
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85116800769
dc.identifier.scopusqualityQ4
dc.identifier.startpage547
dc.identifier.urihttps://doi.org/10.12996/gmj.2021.123
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9115
dc.identifier.volume32
dc.identifier.wosWOS:000726736200009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTozkır, Hilmi
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThyroid carcinoma
dc.subjectGWAS
dc.subjectgenetic risk
dc.subjectSusceptibility Loci
dc.subjectGene Polymorphism
dc.subjectCommon Variants
dc.subjectCarcinoma
dc.titleInvestigation of the Relationship Between Genome Wide Association Studies-derived Polymorphisms and Differentiated Thyroid Cancer Risk in a Turkish Population
dc.title.alternativeBir Türk Popülasyonunda Genom Çapında İlişkilendirme Çalışmalarından Kaynaklanan Polimorfizmler ile Farklılaşmış Tiroid Kanseri Riski Arasındaki İlişkinin İncelenmesi]
dc.typeArticle

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