Effects of Remote Ischemic Conditioning Methods on Ischemia-Reperfusion Injury in Muscle Flaps: An Experimental Study in Rats

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dc.authorid0000-0002-4011-1931
dc.authorscopusid56850131700
dc.authorscopusid6701570903
dc.authorscopusid16024976400
dc.authorscopusid56114794700
dc.authorscopusid55906927700
dc.authorscopusid10641651900
dc.contributor.authorKeskin, Durdane
dc.contributor.authorÜnlü, Ramazan Erkin
dc.contributor.authorOrhan, Erkan
dc.contributor.authorErkilinc, Gamze
dc.contributor.authorBoğdaycıoğlu, Nihal
dc.contributor.authorYılmaz, Fatma Meric
dc.date.accessioned2022-05-11T14:36:52Z
dc.date.available2022-05-11T14:36:52Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractBackground The aim of this study was to investigate the effects of remote ischemic conditioning on ischemia-reperfusion injury in rat muscle flaps histopathologically and biochemically. Methods Thirty albino rats were divided into 5 groups. No procedure was performed in the rats in group 1, and only blood samples were taken. A gracilis muscle flap was elevated in all the other groups. Microclamps were applied to the vascular pedicle for 4 hours in order to achieve tissue ischemia. In group 2, no additional procedure was performed. In groups 3, 4, and 5, the right hind limb was used and 3 cycles of ischemia-reperfusion for 5 minutes each (total, 30 minutes) was applied with a latex tourniquet (remote ischemic conditioning). In group 3, this procedure was performed before flap elevation (remote ischemic preconditoning). In group 4, the procedure was performed 4 hours after flap ischemia (remote ischemic postconditioning). In group 5, the procedure was performed after the flap was elevated, during the muscle flap ischemia episode (remote ischemic perconditioning). Results The histopathological damage score in all remote conditioning ischemia groups was lower than in the ischemic-reperfusion group. The lowest histopathological damage score was observed in group 5 (remote ischemic perconditioning). Conclusions The nitric oxide levels were higher in the blood samples obtained from the remote ischemic perconditioning group. This study showed the effectiveness of remote ischemic conditioning procedures and compared their usefulness for preventing ischemi-are perfusion injury in muscle flaps.
dc.identifier.doi10.5999/aps.2017.44.5.384
dc.identifier.endpage389
dc.identifier.issn2234-6163
dc.identifier.issn2234-6171
dc.identifier.issue5en_US
dc.identifier.pmid28946719
dc.identifier.scopus2-s2.0-85030096965
dc.identifier.scopusqualityQ2
dc.identifier.startpage384
dc.identifier.urihttps://doi.org/10.5999/aps.2017.44.5.384
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8447
dc.identifier.volume44
dc.identifier.wosWOS:000416991000005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOrhan, Erkan
dc.language.isoen
dc.publisherKorean Soc Plastic & Reconstructive Surgery
dc.relation.ispartofArchives of Plastic Surgery-Aps
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIschemic preconditioning
dc.subjectReperfusion injury
dc.subjectIschemia
dc.subjectNitric-Oxide
dc.subjectSkeletal-Muscle
dc.subjectMyocardial-Infarction
dc.subjectReconstruction
dc.subjectModel
dc.subjectProtection
dc.subjectMechanism
dc.subjectBreast
dc.subjectLiver
dc.titleEffects of Remote Ischemic Conditioning Methods on Ischemia-Reperfusion Injury in Muscle Flaps: An Experimental Study in Rats
dc.typeArticle

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