Tuberculin skin test before biologic and targeted therapies: does the same rule apply for all?

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dc.authoridAkar, Servet/0000-0002-3734-1242
dc.authoridKoca, Suleyman Serdar/0000-0003-4995-430X
dc.authoridKaradag, Omer/0000-0002-3443-3117
dc.authoridAlpay Kanitez, Nilufer/0000-0003-1185-5816
dc.authoridemmungil, hakan/0000-0001-5184-4404
dc.authoridGonullu, Emel/0000-0002-6990-4206
dc.authoriderden, abdulsamet/0000-0002-8084-2018
dc.authorscopusid55964991700
dc.authorscopusid14630767100
dc.authorscopusid36805552500
dc.authorscopusid14422446100
dc.authorscopusid55667445900
dc.authorscopusid37114171300
dc.authorscopusid24536798400
dc.authorwosidKaradag, Omer/I-9042-2013
dc.authorwosidGonullu, Emel/A-9240-2018
dc.contributor.authorİlgen, Ufuk
dc.contributor.authorKaradağ, Ömer
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorKüçükşahin, Orhan
dc.contributor.authorKoca, Süleyman Serdar
dc.contributor.authorErden, Abdulsamet
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorMercan, Rıdvan
dc.date.accessioned2023-04-20T08:01:15Z
dc.date.available2023-04-20T08:01:15Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThis study aimed to compare Tuberculin Skin Test (TST) and QuantiFERON (R)-TB Gold In-Tube (QFT-GIT) test in rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients scheduled for biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs) in a Bacillus Calmette-Guerin-vaccinated population. Adult RA (n = 206) and SpA (n = 392) patients from the TReasure database who had both TST and QFT-GIT prior to initiation of biological and targeted synthetic DMARDs were included in the study. Demographic and disease characteristics along with pre-biologic DMARD and steroid use were recorded. The distribution of TST and performance with respect to QFT-GIT were compared between RA and SpA groups. Pre-biologic conventional DMARD and steroid use was higher in the RA group. TST positivity rates were 44.2% in RA and 69.1% in SpA for a 5 mm cutoff (p < 0.001). Only 8.9% and 15% of the patients with RA and SpA, respectively, tested positive by QFT-GIT. The two tests poorly agreed in both groups at a TST cutoff of 5 mm and increasing the TST cutoff only slightly increased the agreement. Among age, sex, education and smoking status, pre-biologic steroid and conventional DMARD use, disease group, and QFT-GIT positivity, which were associated with a 5 mm or higher TST, only disease group (SpA) and QFT-GIT positivity remained significant in multiple logistic regression. TST positivity was more pronounced in SpA compared to that in RA and this was not explainable by pre-biologic DMARD and steroid use. The agreement of TST with QFT-GIT was poor in both groups. Using a 5 mm TST cutoff for both diseases could result in overestimating LTBI in SpA.
dc.identifier.doi10.1007/s00296-022-05134-z
dc.identifier.endpage1806
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue10en_US
dc.identifier.pmid35486197
dc.identifier.scopus2-s2.0-85129018736
dc.identifier.scopusqualityQ2
dc.identifier.startpage1797
dc.identifier.urihttps://doi.org/10.1007/s00296-022-05134-z
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10821
dc.identifier.volume42
dc.identifier.wosWOS:000788942000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİlgen, Ufuk
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArthritis
dc.subjectSpondyloarthritis
dc.subjectInterferon-Gamma Release Tests
dc.subjectTuberculin Test
dc.subjectLatent Tuberculosis
dc.subjectGamma Release Assays
dc.subjectClinical-Practice Guidelines
dc.subjectQuantiferon-Tb-Gold
dc.subjectLatent Tuberculosis
dc.subjectRheumatoid-Arthritis
dc.subjectClassification Criteria
dc.subjectActive Tuberculosis
dc.subjectItalian Society
dc.subjectDisease-Control
dc.subjectInfection
dc.titleTuberculin skin test before biologic and targeted therapies: does the same rule apply for all?
dc.typeArticle

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