Hepatoprotective Activity of Linalool in Rats Against Liver Injury Induced by Carbon Tetrachloride

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dc.authorid0000-0002-6845-2279
dc.authorid0000-0002-9716-0697
dc.authorid0000-0003-3544-9214
dc.authorwosidTekeli, Ibrahim Ozan/W-3685-2017
dc.authorwosidGÜVENÇ, MEHMET/W-3408-2017
dc.authorwosidKAYA, Durmuş Alpaslan/T-4746-2019
dc.contributor.authorAltınok Yipel, Fulya
dc.contributor.authorTekeli, İbrahim Ozan
dc.contributor.authorYurdagül Özsoy, Şule
dc.contributor.authorGüvenç, Mehmet
dc.contributor.authorKaya, Alpaslan
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2022-05-11T14:05:14Z
dc.date.available2022-05-11T14:05:14Z
dc.date.issued2020
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThis study aimed to investigate and compare hepatoprotective activity of Coriandrum sativum (Cs) and it is major component linalool (Ln) against experimentally induced hepatotoxicity in rats. Essential oil of Cs was isolated by hydrodistillation method and chemical composition was determined by GS-MS analysis. 42 male Wistar Albino rats were divited into 7 groups each containing 6. The experimental groups were designed as: Normal control group, 1 ml/kg CCl4 administirated group, 25 mg/kg Silymarin and CCl4 administirated group, 100 and 200 mg/kg Cs and CCl4 administirated groups, 100 and 200 mg/kg Ln and CCl4 administered groups. The protective activities were determined according to the results of liver biomarkers (AST, ALT, ALP), antioxidant parameters (GSH, GPx, CAT), lipid peroxidation (MDA) and histopathological examination. Linalool percentage of Cs was 81.6%. The groups treated with linalool (100 and 200 mg/kg) (p < 0.01) and coriander (200 mg/kg) (p < 0.05) had significantly reduced AST (262-375) and ALT (101-290) levels (U/L) compared to the CCl4 (600-622) group. The levels (nmol/g protein) of MDA (11-12) were significantly lower (p < 0.01), the levels of GSH (11-12) and the activities of CAT (23-24) were significantly higher (p < 0.01) in linalool groups (100 and 200 mg/kg) compared to the CCl4 (18-5-10 respectively) group. These results were also supported by histopathological findings and indicate that Cs and Ln shows hepatoprotective activity against liver damage. In this regard, evaluation of activities of major components are needed to compare to medicinal plants in experimental diseases models.
dc.identifier.doi10.1024/0300-9831/a000581
dc.identifier.endpage308
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue45385en_US
dc.identifier.pmid30932786
dc.identifier.startpage302
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000581
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4930
dc.identifier.volume90
dc.identifier.wosWOS:000540719600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAltınok Yipel, Fulya
dc.institutionauthorYipel, Mustafa
dc.language.isoen
dc.publisherVerlag Hans Huber
dc.relation.ispartofInternational Journal For Vitamin And Nutrition Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon tetrachloride
dc.subjectCoriandrum sativum
dc.subjecthepatoprotective
dc.subjectlinalool
dc.subjectCoriandrum-Sativum L.
dc.subjectEssential Oil
dc.subjectInduced Hepatotoxicity
dc.subjectLipid-Peroxidation
dc.subjectOxidative Stress
dc.subjectAntioxidant
dc.subjectExtract
dc.subjectTissue
dc.titleHepatoprotective Activity of Linalool in Rats Against Liver Injury Induced by Carbon Tetrachloride
dc.typeArticle

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