Calcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting

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dc.authorscopusid6603239395
dc.authorscopusid8713588200
dc.authorscopusid7004214393
dc.authorscopusid6508166517
dc.authorscopusid23992419200
dc.authorscopusid7005332561
dc.contributor.authorBeşirli, K.
dc.contributor.authorAydemir, Birsen
dc.contributor.authorArslan, C.
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorCantürk, E.
dc.contributor.authorKayhan, B.
dc.date.accessioned2022-05-11T14:41:20Z
dc.date.available2022-05-11T14:41:20Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBackground: Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters. It is an antioxidant that increases endothelialderived vasodilator substance secretion, there are none that analyze its effects during the postoperative period of patients undergoing myocardial revascularization. Objective: We aimed to determine the effects of calcium dobesilate on hemorheological parameters, such as reduced glutathione and malondialdehyde in patients with ischemic heart disease undergoing myocardial revascularization in the postoperative period. Methods: One hundred and thirty-four patients operated for coronary heart disease were included in this study. Hemorheological, oxidant and antioxidant parameters were measured two days after surgery and after a period of treatment with calcium dobesilate. Then, 500 mg of calcium dobesilate was given twice a day to one group of 68 patients for three months. The control group was composed of 66 patients who did not receive this medication. Results: The increase in the erythrocyte deformability index was found to be significant compared with both the pretreatment values and with the 1st and 2nd values of the control group after calcium dobesilate administration, whereas there were no significant changes in blood viscosity, glutathione (GSH) or malondialdehyde (MDA) values after the calcium dobesilate administration. The same improvement in the CCS class was observed in patients regardless of they received the calcium dobesilate treatment. Conclusion: In the present investigation, the same improvement in the CCS class was observed in patients regardless of they received the calcium dobesilate treatment. Improvements with calcium dobesilate were statistically significant only in the increase in erythrocyte flexibility.
dc.identifier.doi10.5935/1678-9741.20120057
dc.identifier.endpage266
dc.identifier.issn0102-7638
dc.identifier.issue2en_US
dc.identifier.pmid22996977
dc.identifier.scopus2-s2.0-84866994981
dc.identifier.scopusqualityQ3
dc.identifier.startpage260
dc.identifier.urihttps://doi.org/10.5935/1678-9741.20120057
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9148
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.relation.ispartofBrazilian Journal of Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerosis
dc.subjectCoronary artery bypass
dc.subjectCoronary artery disease
dc.subjectantioxidant
dc.subjectdobesilate calcium
dc.subjectfibrinogen
dc.subjectglutathione
dc.subjecthemostatic agent
dc.subjectmalonaldehyde
dc.subjectaged
dc.subjectanalysis of variance
dc.subjectarticle
dc.subjectblood
dc.subjectblood rheology
dc.subjectblood viscosity
dc.subjectcoronary artery bypass graft
dc.subjectdrug effect
dc.subjecterythrocyte
dc.subjectfemale
dc.subjectheart muscle ischemia
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnonparametric test
dc.subjectpostoperative period
dc.subjectAged
dc.subjectAnalysis of Variance
dc.subjectAntioxidants
dc.subjectBlood Viscosity
dc.subjectCalcium Dobesilate
dc.subjectCoronary Artery Bypass
dc.subjectErythrocytes
dc.subjectFemale
dc.subjectFibrinogen
dc.subjectGlutathione
dc.subjectHemorheology
dc.subjectHemostatics
dc.subjectHumans
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectMiddle Aged
dc.subjectMyocardial Ischemia
dc.subjectPostoperative Period
dc.subjectStatistics, Nonparametric
dc.titleCalcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting
dc.title.alternativeDobesilato de cálcio pode melhorar hemorreologia em pacientes submetidos à cirurgia de revascularização miocárdica]
dc.typeArticle

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