The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex

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dc.authorid0000-0002-6523-5607
dc.authorid0000-0002-6683-5495
dc.authorscopusid12752439300
dc.authorscopusid6603136404
dc.authorscopusid57207569976
dc.authorscopusid14833921600
dc.authorscopusid55960443600
dc.authorscopusid56223188000
dc.authorscopusid55765403800
dc.authorwosidMollaoglu, Hakan/C-6987-2013
dc.contributor.authorEser, Olcay
dc.contributor.authorSongur, Ahmet
dc.contributor.authorYaman, Mehmet
dc.contributor.authorCoşar, Murat
dc.contributor.authorFidan, Hüseyin
dc.contributor.authorŞahin, Onder
dc.contributor.authorBüyükbaş, Sadık
dc.date.accessioned2022-05-11T14:36:54Z
dc.date.available2022-05-11T14:36:54Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObject. We investigated the protective effects of avocado/soybean unsaponifiables (ASU) on the prefrontal cortex (PFC) after global brain ischemia/reperfusion (I/R) injury in rats. Methods. Rats were randomly divided into three experimental groups as follows: Group I was control rats, Group II was ischemia rats, Group III was Isch+ASU rats. Brain ischemia was produced via four-vessel occlusion model. These processes followed by reperfusion for 30 min for both II and III groups. Rats were sacrificed and their brains were removed immediately. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in left PFC, levels of TNF-alpha concentration were measured in the plasma. The number of apoptotic neurons was assayed in histological samples of the right PFC. Results. MDA and TNF-alpha levels as well as the number of apoptotic neurons were observed to have decreased significantly in Group III compared to Group II, while SOD activities have been found to have increased significantly in Group III in comparison to Group II, significantly. Conclusions. We think that ASU might have an antioxidant and neuroprotective effects in brain I/R injured rats.
dc.description.sponsorshipKocatepe University Scientific Research CommitteeAfyon Kocatepe University [051.TIP.14]
dc.description.sponsorshipThis study was supported by the Kocatepe University Scientific Research Committee (Project no. 051.TIP.14). The authors alone are responsible for the content and writing of the paper.
dc.identifier.doi10.3109/02688697.2010.520767
dc.identifier.endpage706
dc.identifier.issn0268-8697
dc.identifier.issn1360-046X
dc.identifier.issue6en_US
dc.identifier.pmid20874457
dc.identifier.scopus2-s2.0-82355195023
dc.identifier.scopusqualityQ3
dc.identifier.startpage701
dc.identifier.urihttps://doi.org/10.3109/02688697.2010.520767
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8468
dc.identifier.volume25
dc.identifier.wosWOS:000297337800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Onder
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBritish Journal of Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAvocado/soybean unsaponifiables
dc.subjectbrain ischemia/reperfusion
dc.subjectprefrontal cortex
dc.subjectIschemia-Reperfusion Injury
dc.subjectEssential Fatty-Acids
dc.subjectSuperoxide-Dismutase
dc.subjectSoy Protein
dc.subjectTnf-Alpha
dc.subjectCerebral-Ischemia
dc.subjectGene-Expression
dc.subjectUnsaponifiables
dc.subjectHippocampus
dc.subjectDamage
dc.titleThe protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex
dc.typeArticle

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