Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries

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dc.contributor.authorUcar, Okan
dc.contributor.authorOzturk, Ibrahim I.
dc.contributor.authorGrzeskiewicz, Anita M.
dc.contributor.authorKubicki, Maciej
dc.contributor.authorBanti, Christina
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2025-04-06T12:23:53Z
dc.date.available2025-04-06T12:23:53Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr2(kappa 2-N3, S-Hatetsc)]} (1) and {[SbCl2(eta 1-S-Hatmtsc)(kappa 2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.
dc.description.sponsorshipTekirdag Namimath;k Kemal UEniversitesi, Office of Scientific Research Projects [NKUBAP.01. DR.21.293]
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the Ph.D. thesis of O.U. under the supervision of I.I.O. This research was promoted by the Tekirdag Nam & imath;k Kemal UEniversitesi, Office of Scientific Research Projects (project no. NKUBAP.01. DR.21.293) .
dc.identifier.doi10.1016/j.ica.2025.122627
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-86000368099
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ica.2025.122627
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17237
dc.identifier.volume581
dc.identifier.wosWOS:001444149400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250406
dc.subjectacetylthiophene thiosemicarbazone
dc.subjectAnticancer activity
dc.subjectAntimicrobial activity
dc.subjectAntimony(III)
dc.subjectCrystal structure
dc.titleSynthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries
dc.typeArticle

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