Ovarian functions and polycystic ovary syndrome in adult women with type 1 diabetes mellitus in a Turkish population

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dc.contributor.authorUrhan, E.
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorHacıoğlu, A.
dc.contributor.authorKaraca, Z.
dc.contributor.authorÜnlühazırcı, K.
dc.contributor.authorKelestimur, F.
dc.date.accessioned2023-05-06T17:23:32Z
dc.date.available2023-05-06T17:23:32Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose The effect of gonadotropin-releasing hormone agonist (GnRHa) stimulation has not been studied in adult women with type 1 diabetes mellitus (DM). We investigated the baseline and stimulated hormone levels after GnRHa and the frequency and relationship between polycystic ovary syndrome (PCOS) and type 1 DM in adult women with type 1 DM. Methods We included 55 adult women (age, 17-35 years) with type 1 DM and 15 healthy women (age, 20-29 years). Hormones including total testosterone, androstenedione, dehydroepiandrosterone sulphate (DHEAS), follicle-stimulating hormone (FSH), luteinising hormone (LH), estradiol, prolactin, and thyroid-stimulating hormone were measured in the early follicular phase of the menstrual cycle. All participants underwent GnRHa stimulation test, and FSH, LH, estradiol and 17-OHP response levels were measured every 6 h for 24 h. PCOS was diagnosed according to ESHRE/ASRM (Rotterdam) criteria. Results Between patients with type 1 DM and healthy controls, no significant differences were noted in mean age and body mass index (BMI) as well as baseline and stimulated hormone levels after buserelin stimulation, except for baseline serum 17-OHP levels, which was higher in patients with type 1 DM. Polycystic ovary morphology (PCOM) was detected in 14 (25%) patients, clinical hyperandrogenism in 16 (29%), hyperandrogenemia in 25 (45%), anovulatory cycle in 72%, and PCOS in 20 (36%). Conclusion All parameters representing androgen excess disorders, except 17-OHP level, of both groups were similar, and frequencies of PCOS and anovulatory cycle in adult women with type 1 DM were 36% and 72%, respectively.
dc.description.sponsorshipSociety of Endocrinology and Metabolism of Turkey
dc.description.sponsorshipPreparation for publication of this article is supported by the Society of Endocrinology and Metabolism of Turkey.
dc.identifier.doi10.1007/s40618-022-01946-9
dc.identifier.endpage616
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue3en_US
dc.identifier.pmid36308639
dc.identifier.scopus2-s2.0-85140822172
dc.identifier.scopusqualityQ2
dc.identifier.startpage609
dc.identifier.urihttps://doi.org/10.1007/s40618-022-01946-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12130
dc.identifier.volume46
dc.identifier.wosWOS:000875788800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorElbüken, Gülşah
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal Of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectType 1 diabetes mellitus
dc.subjectOvarian functions
dc.subjectPolycystic ovary syndrome (PCOS)
dc.subjectAdult women
dc.subjectTurkish population
dc.subjectDiagnostic-Criteria
dc.subjectLuteinizing-Hormone
dc.subjectYoung-Women
dc.subjectPrevalence
dc.subjectGirls
dc.subjectHyperandrogenism
dc.subjectMechanisms
dc.subjectMorphology
dc.subjectPuberty
dc.subjectHealth
dc.titleOvarian functions and polycystic ovary syndrome in adult women with type 1 diabetes mellitus in a Turkish population
dc.typeArticle

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