Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats

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dc.authorid0000-0001-7121-6077
dc.authorid0000-0002-6396-3168
dc.authorscopusid36608599700
dc.authorscopusid55881189500
dc.authorscopusid37058172000
dc.authorscopusid15844109600
dc.authorscopusid6701472672
dc.authorscopusid29067811700
dc.authorscopusid8666331800
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.contributor.authorMete, Rafet
dc.contributor.authorOran, Mustafa
dc.contributor.authorTopçu, Birol
dc.contributor.authorÖznur, Meltem
dc.contributor.authorSeber, Erdoğan Selcuk
dc.contributor.authorGedikbaşı, Asuman
dc.contributor.authorYetişyiğit, Tarkan
dc.date.accessioned2022-05-11T14:07:43Z
dc.date.available2022-05-11T14:07:43Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractBackground/aim: Doxorubicin (DOX) is a widely used and potent chemotherapeutic agent. However, serious dose-limiting toxicity through generation of free oxygen radicals is a commonly encountered clinical problem. The aim of the current study was to assess the protective role of onion (Allium cepa) extract (ACE) against DOX-induced hepatotoxicity in rats. Method: A total of 24 rats were randomly divided into 3 equal experimental groups: (1) DOX; (2) ACE + DOX; and (3) control groups. ACE was given orally as 1 mL of fresh ACE juice for 14 consecutive days followed by DOX injection. DOX was injected intraperitoneally in a single dose of 30 mg/kg body weight to induce hepatotoxicity, and the rats were killed after 48 h from injection. Control group was given saline only. Results: In the ACE pretreated group (ACE + DOX), serum aspartate transaminase, alanine transaminase, and tissue malondialdehyde and glutathione levels were significantly lower, while superoxide dismutase and glutathione peroxidase were higher compared with the DOX group. The histopathological examination of liver specimens revealed parenchymal necrosis, proliferation of biliary duct in DOX group; while ACE pretreatment provided marked reduction in these changes. Conclusion: Our study indicates that pretreatment with ACE protects against DOX-induced hepatotoxicity due to the antioxidant properties of ACE. Further studies on efficacy of antioxidant treatment by ACE in DOX-mediated toxicity and underlying mechanisms would provide a better explanation.
dc.identifier.doi10.1177/0748233713504807
dc.identifier.endpage557
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue3en_US
dc.identifier.pmid24193056
dc.identifier.scopus2-s2.0-84961238407
dc.identifier.scopusqualityQ3
dc.identifier.startpage551
dc.identifier.urihttps://doi.org/10.1177/0748233713504807
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5181
dc.identifier.volume32
dc.identifier.wosWOS:000371603500017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMete, Rafet
dc.institutionauthorOran, Mustafa
dc.institutionauthorTopçu, Birol
dc.institutionauthorÖznur, Meltem
dc.institutionauthorYetişyiğit, Tarkan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute toxicity
dc.subjectanimal model
dc.subjectliver
dc.subjecthepatic toxicity
dc.subjectanti-inflammatory
dc.subjectLipid-Peroxidation
dc.subjectAdriamycin
dc.subjectCardiotoxicity
dc.subjectToxicity
dc.subjectLiver
dc.subjectGlutathione
dc.subjectInhibition
dc.subjectErdosteine
dc.subjectNicotine
dc.subjectAcid
dc.titleProtective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats
dc.typeArticle

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