Trophoblast Cell Proliferation and Apoptosis in Placental Development During Early Gestation Period in Rats

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dc.authorscopusid36023238400
dc.authorscopusid7006356462
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorKanter, Mehmet
dc.date.accessioned2022-05-11T14:41:28Z
dc.date.available2022-05-11T14:41:28Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To show apoptotic and mitotic activities in differentiation and proliferation of the trophoblast through the techniques of immunohistochemistry and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL), apart from achieving a morphological examination of placental development during early gestation in rats. STUDY DESIGN: Animals were sacrificed on days 7, 9, 11, and 13 of pregnancy. The samples removed from those rats were processed for purposes of microscopic analysis. The decidual structure resulting from the differentiation of the endometrial stromal cells in the uterus on days 7, 9, and 11 of pregnancy was determined. RESULTS: It was observed that the placenta, with an increasing trophoblast proliferation and differentiation, matures on day 13 of pregnancy, after which time the growth seems to be continuous. Density of PCNA-positive cells and PCNA immunostaining was observed to decrease in parallel with the age of pregnancy. The excessive number of apoptotic cells seen in the early periods of pregnancy decreased as the placenta matured. CONCLUSION: We speculate that the rat placenta grows to maturity by day 13 of pregnancy along with increased proliferation and apoptosis in the early days of pregnancy. In addition, a significant decrease of proliferation and apoptosis was observed in the placenta with increasing age of the pregnancy.
dc.description.sponsorshipTrakya University Research Center, Edirne, TurkeyTrakya University [TUBAP-2010/31]
dc.description.sponsorshipFunded by the Trakya University Research Center, Edirne, Turkey (project TUBAP-2010/31).
dc.identifier.endpage294
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid26856113
dc.identifier.scopus2-s2.0-84947932193
dc.identifier.scopusqualityN/A
dc.identifier.startpage286
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9191
dc.identifier.volume37
dc.identifier.wosWOS:000367870000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapoptosis
dc.subjectembryology
dc.subjectPCNA
dc.subjectplacental development
dc.subjectplacentation
dc.subjecttrophoblast
dc.subjectproliferating cell nuclear antigen
dc.subjectrats
dc.subjectlaboratory
dc.subjectGrowth Restriction
dc.subjectMouse
dc.subjectImplantation
dc.subjectExpression
dc.subjectPregnancy
dc.subjectDifferentiation
dc.subjectPatterns
dc.subjectInvasion
dc.subjectAge
dc.titleTrophoblast Cell Proliferation and Apoptosis in Placental Development During Early Gestation Period in Rats
dc.typeArticle

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