Soluble endothelial protein C is associated with blood pressure variability and salt consumption but not mean blood pressure in patients with newly diagnosed primary hypertension

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dc.authorid0000-0003-2520-6825
dc.authorscopusid8570900600
dc.authorscopusid57190404723
dc.authorscopusid57202336559
dc.authorscopusid23968920100
dc.authorscopusid6603926071
dc.authorwosidFidan, Cigdem/X-7070-2018
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorFidan, Çiğdem
dc.contributor.authorGüzel, Savaş
dc.contributor.authorUlusoy, Şükrü
dc.date.accessioned2022-05-11T14:14:04Z
dc.date.available2022-05-11T14:14:04Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: Hypertension is a widespread disease involving frequent thrombotic complications. Blood pressure variability (BPV) has recently been shown to be associated with end-organ damage and cardiovascular events. However, the pathogenesis of the relation between BPV and cardiovascular events has not yet been explained. Soluble endothelial protein C (sEPCR) exhibits a procoagulant effect by reducing the anticoagulant and anti-inflammatory effects of protein C and activated protein C. The purpose of this study was to evaluate sEPCR levels in hypertensive individuals and the parameters affecting that level, particularly BPV. Methods: Fifty-one newly diagnosed hypertensive subjects and 31 healthy individuals were included in the study. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed after office control, and simultaneous 24-h urine was collected. BPV was calculated with average real variability (ARV) from ABPM data. Blood specimens were collected under appropriate conditions for sEPCR levels and biochemical tests. sEPCR levels were compared between the patient and healthy groups, after which parameters affecting sEPCR elevation in the hypertensive group were evaluated. Results: sEPCR levels were significantly high in the hypertensive group (p < 0.05). At multivariate regression analysis in the hypertensive group, sEPCR was determined to be independently associated with 24-h systolic ARV (beta = 0.572, p < 0.05) and 24-h urine Na (beta = 0.428, p < 0.05). Conclusion: In our study, sEPCR was high in hypertensive individuals, and this elevation was related to ARV and urine Na excretion independently of mean blood pressure.
dc.identifier.doi10.1080/10641963.2018.1481425
dc.identifier.endpage358
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue4en_US
dc.identifier.pmid29851520
dc.identifier.scopus2-s2.0-85047959742
dc.identifier.scopusqualityQ3
dc.identifier.startpage353
dc.identifier.urihttps://doi.org/10.1080/10641963.2018.1481425
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5768
dc.identifier.volume41
dc.identifier.wosWOS:000463617800008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorFidan, Çiğdem
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofClinical and Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypertension
dc.subjectsoluble endothelial protein C
dc.subjectsEPCR
dc.subjectblood pressure variability
dc.subjectBPV
dc.subjectAngiotensin-Ii
dc.subjectRisk-Factor
dc.subjectUric-Acid
dc.subjectReceptor
dc.subjectFibrinolysis
dc.subjectAmlodipine
dc.subjectMarker
dc.subjectSepcr
dc.subjectIndex
dc.titleSoluble endothelial protein C is associated with blood pressure variability and salt consumption but not mean blood pressure in patients with newly diagnosed primary hypertension
dc.typeArticle

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