Investigation of the peripheral inflammation (neutrophil-lymphocyte ratio) in two neurodegenerative diseases of the central nervous system

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dc.authorscopusid57190404723
dc.authorscopusid57211906388
dc.authorscopusid16069377400
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorAltunan, Bengü
dc.contributor.authorÜnal, A.
dc.date.accessioned2022-05-11T14:02:50Z
dc.date.available2022-05-11T14:02:50Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIntroduction: Alzheimer’s disease (AD), and idiopathic Parkinson’s disease (IPD) are the neurodegenerative diseases of the central nervous system (CNS). Cognitive impairment is on the forefront in AD. However, IPD is a movement disorder. Inflammation was suggested to have an effect in the pathophysiology of these two diseases. Neutrophil–lymphocyte ratio (NLR) was shown to be a possible marker showing the peripheral inflammation. We aimed to investigate the NLR of patiens with the diagnosis of AD, and IPD, and individuals with no neurodegenerative disease. Materials and methods: A total of 100 patients with the diagnosis of IPD, and 94 with diagnosis of AD, and 61 healthy controls were included into the study. All the demographic, clinical, and laboratory data were retrospectively obtained from the hospital automated database system. Results: The NLR in the IPD group was found statistically significantly higher compared with the control group and the AD group (p < 0.001, p = 0.04, respectively). The age-adjusted values were statistically analyzed because of age difference. No statistically significant difference was detected between AD and control groups in terms of NLR (p = 0.6). The age-adjusted NLR value in the Parkinson’s group was found significantly higher compared to the control group (p = 0.02) and Alzheimer’s group (p = 0.03). Discussion: Chronic inflammation has an important role in the emergence and progression of the chronic neurodegenerative diseases of the CNS. Our results show that the inflammation in the peripheral blood in IPD was more significant compared with the inflammation in AD. © 2021, Fondazione Società Italiana di Neurologia.
dc.identifier.doi10.1007/s10072-021-05507-5
dc.identifier.endpage1807
dc.identifier.issn1590-1874
dc.identifier.issue3en_US
dc.identifier.pmid34331157
dc.identifier.scopus2-s2.0-85111509486
dc.identifier.scopusqualityQ1
dc.identifier.startpage1799
dc.identifier.urihttps://doi.org/10.1007/s10072-021-05507-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4508
dc.identifier.volume43
dc.identifier.wosWOS:000679595900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorAltunan, Bengü
dc.institutionauthorÜnal, A.
dc.language.isoen
dc.publisherSpringer-Verlag Italia s.r.l.
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s disease
dc.subjectNeutrophil–lymphocyte ratio
dc.subjectParkinson’s disease
dc.subjectPeripheral inflammation
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectAlzheimer disease
dc.subjectArticle
dc.subjectautomation
dc.subjectClinical Dementia Rating
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdata base
dc.subjectdemographics
dc.subjectdisease duration
dc.subjectDSM-IV
dc.subjectfemale
dc.subjecthuman
dc.subjectidiopathic disease
dc.subjectinflammation
dc.subjectleukocyte count
dc.subjectlymphocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmonocyte
dc.subjectmonocyte count
dc.subjectneutrophil count
dc.subjectneutrophil lymphocyte ratio
dc.subjectonset age
dc.subjectParkinson disease
dc.subjectplatelet count
dc.subjectpredictive value
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectcentral nervous system
dc.subjectdegenerative disease
dc.subjectinflammation
dc.subjectlymphocyte
dc.subjectneutrophil
dc.subjectCentral Nervous System
dc.subjectHumans
dc.subjectInflammation
dc.subjectLymphocytes
dc.subjectNeurodegenerative Diseases
dc.subjectNeutrophils
dc.subjectRetrospective Studies
dc.titleInvestigation of the peripheral inflammation (neutrophil-lymphocyte ratio) in two neurodegenerative diseases of the central nervous system
dc.typeArticle

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