Polymorphism detection of DGAT1 and Lep genes in Anatolian water buffalo (Bubalus bubalis) populations in Turkey

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dc.authorid0000-0003-2982-6562
dc.authorwosidISIK, RAZIYE/O-2454-2019
dc.contributor.authorIşık, Raziye
dc.contributor.authorÖzkan Ünal, Emel
dc.contributor.authorSoysal, Mehmet İhsan
dc.date.accessioned2022-05-11T14:02:56Z
dc.date.available2022-05-11T14:02:56Z
dc.date.issued2022
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.departmentFakülteler, Ziraat Fakültesi, Zootekni Bölümü
dc.description.abstractAcyl-CoA: diacylglycerol-acyltransferase 1 (DGAT1) enzyme plays a key role in controlling the synthesis rate triglyceride from diacylglycerol. Leptin (LP, OB, obese) is an important hormone that synthesizes mostly from adipose tissue and regulates glucose metabolism and homeostasis. DGAT1 and Lep genes are closely related to reproduction, growth, milk yield and composition in water buffalo breeds. This study aimed to identify genetic variation in the DGAT1 and Lep gene regions in 150 water buffalo individuals from five different provinces of Turkey using DNA sequencing. A total of 38 nucleotide variations and indels have identified 761 bp long partial intron 2 and exon 3 and 5' UTR regions of the Lep gene in Anatolian water buffalo populations; 422 bp long partial exon 7-9 and exon 8 regions of DGAT1 gene were amplified and two mutations were defined in the point of 155 and 275 nucleotide that is three genotypes for S allele and Y allele of DGAT1 gene in intron 7 in Anatolian buffalo populations, respectively. These SNPs may have an effect on reproduction, growth, milk yield and composition in water buffalo populations and may prove to be useful for water buffalo breeding.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Namik Kemal University [NKUBAP.00.24.AR.14.32]; Republic of Turkey Ministry of Agriculture and Forestry General Directorate of Agricultural Research and Policies [TAGEM 13/AR-GE/29]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Coordination Unit of Namik Kemal University, under project number NKUBAP.00.24.AR.14.32, and the Republic of Turkey Ministry of Agriculture and Forestry General Directorate of Agricultural Research and Policies, under project number TAGEM 13/AR-GE/29.
dc.identifier.doi10.5194/aab-65-1-2022
dc.identifier.endpage9
dc.identifier.issn0003-9438
dc.identifier.issn2363-9822
dc.identifier.issue1en_US
dc.identifier.pmid35024434
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.5194/aab-65-1-2022
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4548
dc.identifier.volume65
dc.identifier.wosWOS:000739138800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Raziye
dc.institutionauthorÖzkan Ünal, Emel
dc.institutionauthorSoysal, Mehmet İhsan
dc.language.isoen
dc.publisherCopernicus Gesellschaft Mbh
dc.relation.ispartofArchives Animal Breeding
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiacylglycerol Acyltransferase Dgat1
dc.subjectQuantitative Trait Locus
dc.subjectMilk-Production Traits
dc.subjectFeed-Intake
dc.subjectAssociation
dc.subjectGrowth
dc.subjectYield
dc.subjectIdentification
dc.subjectNucleotide
dc.subjectHusbandry
dc.titlePolymorphism detection of DGAT1 and Lep genes in Anatolian water buffalo (Bubalus bubalis) populations in Turkey
dc.typeArticle

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