Comparison of the Sensititre YeastOne antifungal method with the CLSI M27-A3 reference method to determine the activity of antifungal agents against clinical isolates of Candida spp.

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dc.authorid0000-0003-2535-0480
dc.authorid0000-0002-1237-0864
dc.authorscopusid57188873859
dc.authorscopusid53879441500
dc.authorscopusid57195464291
dc.authorscopusid7005738302
dc.authorscopusid6603895764
dc.authorwosidKiraz, Nuri/AAI-9380-2021
dc.contributor.authorAltinbas, Rabiye
dc.contributor.authorBaris, Ayse
dc.contributor.authorSen, Sumeyye
dc.contributor.authorÖztürk, Recep
dc.contributor.authorKiraz, Nuri
dc.date.accessioned2022-05-11T14:42:11Z
dc.date.available2022-05-11T14:42:11Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground and aim: Infections caused by Candida species are significantly increasing today, and invasive Candida infections are generally associated with high mortality. Early diagnosis and identification of Candida spp. is important for the determination of antifungal agents that will be used for treatment. The aim of the present study was to provide a better regimen for Candida infections in the future. Materials and methods: The Sensititre YeastOne (SYO) method was compared with The Clinical Laboratory Standards Institute ((MS!) reference broth microdilution (BMD) testing method. Endpoints of minimal inhibitory concentrations (MICs) were determined for both methods. Results: By using both methods, MIC values of micafungin, caspofungin, voriconazole, and fluconazole were lower than amphotericin B. The values obtained with the SYO method were in high categorical agreement for ecinocandins and amphotericin B. The results of voriconazole and fluconazole were in low categorical agreement. The categorical agreement between the SYO and the BMD results at 24 h was 82.1% for VORI and 98.4% for AMB. Values obtained with SYO method for all antifungal agents were in high essential agreement with the data of the CLSI reference BMD method. The essential agreement between the SYO and the BMD results at 24 h was 94.0% for MFG and 99.0% for AMB. Conclusions: The SYO method was ready-to use, so it appeared to be easier and more efficient for Candida isolates.
dc.identifier.doi10.3906/sag-1909-97
dc.identifier.endpage2031
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue8en_US
dc.identifier.pmid32659879
dc.identifier.scopus2-s2.0-85098798823
dc.identifier.scopusqualityQ3
dc.identifier.startpage2024
dc.identifier.urihttps://doi.org/10.3906/sag-1909-97
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9269
dc.identifier.volume50
dc.identifier.wosWOS:000600735500034
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKiraz, Nuri
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCandida spp.
dc.subjectantifungal susceptibility
dc.subjectbroth microdilution
dc.subjectsensititre yeastone
dc.subjectsusceptibility test comparison
dc.subjectBroth Microdilution
dc.subjectInvasive Candidiasis
dc.subjectSusceptibility Test
dc.subjectAmphotericin-B
dc.subjectEpidemiology
dc.subjectVoriconazole
dc.subjectPanel
dc.subjectEchinocandins
dc.subjectCaspofungin
dc.subjectFluconazole
dc.titleComparison of the Sensititre YeastOne antifungal method with the CLSI M27-A3 reference method to determine the activity of antifungal agents against clinical isolates of Candida spp.
dc.typeArticle

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