Association between drug resistant hypertension and increased osteoprotegerin levels in hypertensive male patients with non obstructive sleep apnea

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dc.authorid0000-0002-3535-5704
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorOran, Mustafa
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorDeğirmenci, Hasan
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorAlp, Recep
dc.date.accessioned2022-05-11T14:07:35Z
dc.date.available2022-05-11T14:07:35Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage and is related to obstructive sleep apnea (OSA) syndrome and hypertension. Osteoprotegerin OPG is a member of the tumor necrosis factor superfamily and increases leukocyte adhesion. The relationship between increased OPG and atherosclerosis is Well known, but there is still no evidence whether there is an association between OPG and resistant hypertension. This study investigated the association between OPG and drug resistant hypertension in patients With OSA and non-OSA. Patients and methods: We investigated the association between serum OPG levels and carotid IMT in patients With drug resistant hypertensive OSA (ODR) patients (n= 39) and drug resistant hypertensive non-OSA(NODR) patients (n=34) and drug-responsive hypertensive non-OSA controls (n=36). Results: OPG levels and carotid IMT were found to be higher in the ODR [12.4(5.9-19.5) and 0.89 +/- 0.51 and in the NODR group [11.9(5.7-17.6) and 0.88 +/- 0.6] compared with the controls [8.4(4.8-16.5) pmollL and 0.73 +/- 0.8 um], (p= 0.01 and p=0.01 for OPG and p<0.01 and p<0.01 for carotid IMT). The carotid IMT was positively correlated with OPG levels in the ODR. group (r=0.412, p=0.016) and in the NODR group(r=0.321, p=0.024) and with apnea hypopnea index (r=0.462, p<0.001) in the ODR. There was no correlation between OPG and apnea-hypopnea index (r=0.07, p=0.564) in the ODR group. Conclusions: Increased serum OPG levels were associated with subclinical carotid atherosclerosis in patients with ODR and NODR, but not with drug-response non-OSA controls.
dc.identifier.endpage1386
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84944278167
dc.identifier.scopusqualityN/A
dc.identifier.startpage1381
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5149
dc.identifier.volume30
dc.identifier.wosWOS:000364114900035
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorOran, Mustafa
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorDeğirmenci, Hasan
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorAlp, Recep
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarotid intima-media thickness
dc.subjectObsturictive sleep apnea
dc.subjectOsteoprotegerin
dc.subjectdrug resistant hypertension
dc.subjectIntima-Media Thickness
dc.subjectLong-Term Prognosis
dc.subjectSerum Osteoprotegerin
dc.subjectArterial Stiffness
dc.subjectIndicators
dc.subjectPrevalence
dc.subjectObesity
dc.subjectRisk
dc.titleAssociation between drug resistant hypertension and increased osteoprotegerin levels in hypertensive male patients with non obstructive sleep apnea
dc.typeArticle

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