Acute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Study

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dc.authorid0000-0001-9636-4113
dc.authorid0000-0002-1172-8668
dc.authorid0000-0001-9178-2850
dc.authorid0000-0002-3285-417X
dc.authorid0000-0001-5687-8531
dc.authorid0000-0002-2035-9462
dc.authorscopusid57192819391
dc.authorscopusid28568158700
dc.authorscopusid55173827100
dc.authorscopusid8842895600
dc.authorscopusid6603070081
dc.authorscopusid6701664192
dc.authorscopusid25639501700
dc.authorwosidBuyukasik, Yahya/AAJ-3228-2020
dc.authorwosidSevindik, Omur Gokmen/AAD-5452-2021
dc.authorwosidKarakus, Volkan/A-4238-2018
dc.authorwosidDemirkan, Fatih/AAD-6403-2019
dc.authorwosidDogu, Mehmet Hilmi/W-2255-2017
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidCiftciler, Rafiye/AAC-1734-2020
dc.contributor.authorÇiftçiler, Rafiye
dc.contributor.authorSevindik, Omur Gokmen
dc.contributor.authorTekgunduz, Ali Irfan Emre
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorVural, Filiz
dc.contributor.authorTurgut, Burhan
dc.contributor.authorDemirkan, Fatih
dc.date.accessioned2022-05-11T14:37:00Z
dc.date.available2022-05-11T14:37:00Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractObjective: Significant developments occurred in the clinical management of acute lymphoblastic leukemia (ALL) in adults in recent decades. However, treatment results are still not satisfactory, especially in routine practice. The objective of this study was to evaluate the general clinical features, treatment details, and outcomes of a large group of patients followed in multiple centers in Turkey with a diagnosis of ALL. Materials and Methods: A retrospective analysis of the data of patients with ALL was made, the patients having been diagnosed and treated between January 2003 and June 2017 by different protocols in the hematology clinics of ten different centers. A total of 288 patients, aged between 17 and 76 years old, were included in the study. In this retrospective multicenter analysis of patients with ALL, classification of patients was performed based on treatment period, Philadelphia chromosome positivity, treatment regimen, and administration of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Results: The majority of cases were B-cell in origin, while 224 patients had B-ALL and 64 of the patients had T-ALL. Median follow-up duration for all patients was 18.2 months (range: 0.03-161 months). Philadelphia chromosome positivity was determined in 49 patients (21.9%), and 54 patients (18.8%) were receiving allo-HSCT. After induction chemotherapy, 219 patients (76.0%) achieved complete remission, 32 patients (11.2%) were evaluated as treatment refractory, and 37 patients (12.8%) were deceased. Median overall survival was 47.7 months (95% confidence interval: 36.1-59.2) and median disease-free survival was 23.4 months (95% confidence interval: 6.7-40.0) for all patients. Conclusion: Multicenter studies are extremely important for defining the specific clinical features of a particular disease. The results of this study will make a significant contribution to the literature as they reflect real-life data providing valuable information about the Turkish ALL patient profile.
dc.identifier.doi10.4274/tjh.galenos.2019.2019.0008
dc.identifier.endpage177
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid31131598
dc.identifier.scopus2-s2.0-85070409005
dc.identifier.scopusqualityQ3
dc.identifier.startpage169
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2019.2019.0008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8521
dc.identifier.volume36
dc.identifier.wosWOS:000482629200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Burhan
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofTurkish Journal of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute lymphoblastic leukemia
dc.subjectPediatric regimen
dc.subjectPediatric-inspired regimen
dc.subjectPhiladelphia chromosome
dc.subjectChemotherapy
dc.subjectAdults
dc.subjectSurvival
dc.subjectTrial
dc.subjectTherapy
dc.subjectRegimen
dc.subjectAdolescents
dc.subjectImprovement
dc.subjectChildren
dc.titleAcute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Study
dc.title.alternativeRutin uygulamada akut lenfoblastik lösemi: Türkiye'den çok merkezli bir çalışma]
dc.typeArticle

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