Assessing Microstructural, Biomechanical, and Biocompatible Properties of TiNb Alloys for Potential Use as Load-Bearing Implants

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dc.authoridIncesu, Alper/0000-0003-4404-4331
dc.authoridCETIN, YUKSEL/0000-0001-5101-3870
dc.authoridYILDIZHAN, yasemin/0000-0002-5475-070X
dc.contributor.authorKarakurt, Eyyup Murat
dc.contributor.authorHuang, Yan
dc.contributor.authorCetin, Yuksel
dc.contributor.authorIncesu, Alper
dc.contributor.authorDemirtas, Huseyin
dc.contributor.authorKaya, Mehmet
dc.contributor.authorYildizhan, Yasemin
dc.date.accessioned2024-10-29T17:59:23Z
dc.date.available2024-10-29T17:59:23Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractTitanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use in implantology owing to the biomechanical mismatch between the implant and the host tissue. Therefore, to balance the mechanical performance of the load-bearing implant with bone, TiNb alloys with differing porosities were fabricated by powder metallurgy combined with spacer material. Microstructures and phase constituents were characterized with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The mechanical properties were tested by uniaxial compression, and the corrosion performance was determined via a potentiodynamic polarization experiment. To evaluate a highly matched potential implant with the host, biocompatibilities such as cell viability and proliferation rate, fibronectin adsorption, plasmid-DNA interaction, and an SEM micrograph showing the cell morphology were examined in detail. The results showed that the alloys displayed open and closed pores with a uniform pore size and distribution, which allowed for cell adherence and other cellular activities. The alloys with low porosity displayed compressive strength between 618 MPa and 1295 MPa, while the alloys with high porosity showed significantly lower strength, ranging from 48 MPa to 331 MPa. The biological evaluation of the alloys demonstrated good cell attachment and proliferation rates.
dc.description.sponsorshipThe EPSRC Future LiME Hub [EP/N007638/1]; EPSRC Future LiME Hub; Republic of Turkey Ministry of National Education
dc.description.sponsorshipThe EPSRC Future LiME Hub (EP/N007638/1); PhD studentship, the Republic of Turkey Ministry of National Education.
dc.identifier.doi10.3390/jfb15090253
dc.identifier.issn2079-4983
dc.identifier.issue9en_US
dc.identifier.pmid39330229
dc.identifier.scopus2-s2.0-85205246983
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/jfb15090253
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14720
dc.identifier.volume15
dc.identifier.wosWOS:001323970900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Functional Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpowder metallurgy
dc.subjectspacer material
dc.subjectload-bearing implant
dc.subjectcorrosion performance
dc.subjectcytocompatibility
dc.titleAssessing Microstructural, Biomechanical, and Biocompatible Properties of TiNb Alloys for Potential Use as Load-Bearing Implants
dc.typeArticle

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