Disease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: cross-sectional data from the Psoriatic Arthritis-International Database

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dc.authorid0000-0003-4530-2304
dc.authorid0000-0003-3584-2788
dc.authorid0000-0002-2260-4660
dc.authorwosidkucuksahin, orhan/A-9898-2018
dc.authorwosidDuruoz, Mehmet Tuncay/I-2307-2016
dc.authorwosidBilgin, Emre/C-8092-2015
dc.authorwosidGonullu, Emel/AAK-7851-2021
dc.contributor.authorBilgin, E.
dc.contributor.authorAydın, S. Z.
dc.contributor.authorTinazzi, Ilaria
dc.contributor.authorBayındır, Özün
dc.contributor.authorKimyon, G.
dc.contributor.authorÖzişler, Cem
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorMercan, Rıdvan
dc.date.accessioned2022-05-11T14:40:00Z
dc.date.available2022-05-11T14:40:00Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective To explore the impact of early versus late-onset psoriasis (PsO) on the disease characteristics of psoriatic arthritis (PsA) in a large-multicentre cohort. Methods The data from a multicentre psoriatic arthritis database was analysed. Patients were grouped according to age at psoriasis onset (early onset; 40 years of age, late-onset; 40 years of age) and disease characteristics of the groups were compared by adjusting for BMI and PsA duration, where necessary. Results At the time of analyses, 1634 patients were recruited [62.8% females; early onset 1108 (67.8%); late-onset, 526 (32.2%)]. The late-onset group was more over-weight [66.8% vs. 86.8%, p<0.001; adjusted for age -aOR 1.55 (1.11-2.20; 95% CI)]. The early onset group had more scalp psoriasis at onset (56.7% vs. 43.0%, p<0.001), whereas extremity lesions were more common in the late-onset group (63.8% vs. 74.2%, p<0.001). Axial disease in males and psoriatic disease family history in females were significantly higher in the early onset group [38.0% vs. 25.4%; p=0.005; adjusted for PsA duration -aOR 1.76 (1.19-2.62; 95% CI) / 39.5% vs. 30.1%; p=0.003; OR 1.51 (1.15-1.99; 95% CI), respectively]. Psoriatic disease activity parameters, patient-physician reported outcomes and HAQ-DI scores were similar in both groups. Conclusion Clinical features of PsA may be affected by the age at onset of PsO. Different genetic backgrounds in early and late-onset PsO may be driving the differences in psoriasis and PsA phenotypes.
dc.identifier.endpage536
dc.identifier.issn0392-856X
dc.identifier.issn1593-098X
dc.identifier.issue3en_US
dc.identifier.pmid32662407
dc.identifier.scopus2-s2.0-85106479421
dc.identifier.scopusqualityQ2
dc.identifier.startpage532
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8829
dc.identifier.volume39
dc.identifier.wosWOS:000653640600011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherClinical & Exper Rheumatology
dc.relation.ispartofClinical and Experimental Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpsoriasis
dc.subjectpsoriatic arthritis
dc.subjectearly and late-onset
dc.subjectPhenotype
dc.titleDisease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: cross-sectional data from the Psoriatic Arthritis-International Database
dc.typeArticle

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