The relationship between changes in the expression of growth associated protein-43 and functional recovery of the injured inferior alveolar nerve following transection without repair in adult rats

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dc.authorscopusid14630077000
dc.authorscopusid55515412500
dc.authorscopusid24074751600
dc.authorscopusid55885900400
dc.authorscopusid37058172000
dc.authorscopusid57224595858
dc.authorwosidsener, umit/AAZ-7728-2020
dc.contributor.authorCeber, Mehmet
dc.contributor.authorŞener, Ümit
dc.contributor.authorMihmanli, Ahmet
dc.contributor.authorKılıç, Ulkan
dc.contributor.authorTopçu, Birol
dc.contributor.authorKarakas, Merve
dc.date.accessioned2022-05-11T14:10:10Z
dc.date.available2022-05-11T14:10:10Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractObjective: The objective of this study was to analyze the changes in the expression of growth associated protein-43 (GAP-43) in trigeminal ganglions (TGs) and in the distal stumps of transected inferior alveolar nerves (IANs), and to clarify the relationship between these changes and functional recovery of the transected IAN without repair using a rat IAN axotomy model. Material and methods: Following transection, GAP-43 expression was measured at multiple time points. The functional recovery of the transected IAN was evaluated based on the compound muscle action potentials recorded from the digastric muscle. Results: GAP-43 expression in TGs was significantly higher at 2, 7, 14, 28, and 56 days following IAN transection compared to that in samples from sham-operated rats (p < 0.0005, p < 0.0005, p < 0.0005, p = 0.007, and p = 0.023, respectively). GAP-43 expression in the distal stumps of transected IANs was significantly higher at 2, 7, 14, and 28 days following IAN transection compared to that in samples taken from sham rats (p < 0.0005, p < 0.0005, p < 0.0005, and p = 0.009, respectively). GAP-43 expression in the distal stumps of transected IANs returned nearly to sham levels by day 56 following IAN transection. On days 7, 14, 28, and 56 following transection, the amplitude of the compound muscle action potential gradually increased, the latency gradually decreased, and the duration gradually increased. The amplitude, latency, and duration of the compound muscle action potentials nearly returned to sham levels on post-transection day 56. Conclusions: Time-dependent changes in the expression of GAP-43 in both TGs and distal stumps of transected IANs without repair are synchronously consistent with the regeneration and functional recovery of the transected IAN. The recovery of the amplitude, latency, and duration of the compound muscle action potentials indicates increased myelination and increased axon density of the regenerated nerve fibers. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jcms.2015.08.018
dc.identifier.endpage1913
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue9en_US
dc.identifier.pmid26421471
dc.identifier.scopus2-s2.0-84944893072
dc.identifier.scopusqualityQ1
dc.identifier.startpage1906
dc.identifier.urihttps://doi.org/10.1016/j.jcms.2015.08.018
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5311
dc.identifier.volume43
dc.identifier.wosWOS:000364138600031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCeber, Mehmet
dc.institutionauthorŞener, Ümit
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGAP-43
dc.subjectInferior alveolar nerve
dc.subjectTransection
dc.subjectCompound muscle action potentials
dc.subjectNerve regeneration
dc.subjectPrimary Sensory Neurons
dc.subjectRoot Ganglion Neurons
dc.subjectTrigeminal Ganglion
dc.subjectSpinal-Cord
dc.subjectNeuropeptide Expression
dc.subjectGap-43 Expression
dc.subjectAxonal Growth
dc.subjectSciatic-Nerve
dc.subjectDorsal-Horn
dc.subjectRegeneration
dc.titleThe relationship between changes in the expression of growth associated protein-43 and functional recovery of the injured inferior alveolar nerve following transection without repair in adult rats
dc.typeArticle

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