Chemerin and calprotectin levels correlate with disease activity and inflammation markers in psoriasis vulgaris

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dc.authorid0000-0003-0000-5568
dc.authorid0000-0003-0375-1881
dc.authorscopusid23968920100
dc.authorscopusid27867662800
dc.authorscopusid10639223100
dc.authorscopusid42661653300
dc.authorscopusid55481926000
dc.authorscopusid55413116500
dc.authorscopusid6508166517
dc.authorwosidErfan, Gamze/W-8139-2018
dc.authorwosidKızıler, Ali Rıza/ABA-6911-2020
dc.contributor.authorGüzel, Savaş
dc.contributor.authorErfan, Gamze
dc.contributor.authorKulaç, Mustafa
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorKaya, Şule
dc.contributor.authorKızıler, Ali Rıza
dc.date.accessioned2022-05-11T14:07:44Z
dc.date.available2022-05-11T14:07:44Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBackground: Psoriasis is a chronic inflammatory dermatosis that affects about 2-3% of the general population. We aimed to investigate the relationship between serum chemerin and calprotectin levels and the inflammatory markers that can lead to oxidative damage. Methods: Fifty patients with psoriasis and 30 healthy controls were included in the study. Levels of chemerin and calprotectin were measured in addition to levels of C-reactive protein, the erythrocyte sedimentation rate, and the white blood cell count to evaluate inflammation. Results: According to our findings, chemerin and calprotectin levels in the patient group were significantly higher than in the control group (p <0.01 and p < 0.001. respectively). Patients with psoriasis were divided into three groups based on the Psoriasis Area and Severity Index: mild, moderate, and severe. The chemerin levels in the severe and moderate groups were significantly higher than in the mild group (p < 0.01 and p < 0.05, respectively). The calprotectin levels in the severe psoriasis group were also significantly higher than in the mild group (p < 0.05). Similarly, the erythrocyte sedimentation rate and levels of fibrinogen and C-reactive protein were significantly higher in patients with psoriasis than in the control group (p < 0.05, p <0.01. and p < 0.001, respectively). Stepwise regression analysis was used to assess the individual contributing factors. Among these contributing factors, the chemerin levels were observed to be positively correlated with both the Psoriasis Area and Severity Index (R-2 = 0.111) and the calprotectin level (R-2 = 0.445). Calprotectin was observed to be positively correlated with both the C-reactive protein (R-2 = 0.119) and chemerin levels (R-2 = 0.315). Conclusion: The chemerin and calprotectin levels in patients with psoriasis showed that there is an inflammatory process in psoriasis and that these markers are useful indicators of the severity of psoriasis. (C) Copyright 2014, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
dc.description.sponsorshipUniversity Scientific Research Funding
dc.description.sponsorshipThis study was supported by University Scientific Research Funding.
dc.identifier.doi10.1016/j.dsi.2014.08.003
dc.identifier.endpage4
dc.identifier.issn1027-8117
dc.identifier.issn2223-330X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84921369547
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.dsi.2014.08.003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5188
dc.identifier.volume33
dc.identifier.wosWOS:000351032300016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGüzel, Savaş
dc.institutionauthorErfan, Gamze
dc.institutionauthorKulaç, Mustafa
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorKaya, Şule
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofDermatologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcalprotectin
dc.subjectchemerin
dc.subjectinflammation
dc.subjectpsoriasis vulgaris
dc.subjectBinding S100 Proteins
dc.subjectEndothelial-Cells
dc.subjectDifferentiation
dc.subjectKeratinocytes
dc.subjectPathogenesis
dc.subjectLeukocytes
dc.subjectS100a8/A9
dc.subjectCytokines
dc.subjectAdhesion
dc.subjectMediator
dc.titleChemerin and calprotectin levels correlate with disease activity and inflammation markers in psoriasis vulgaris
dc.typeArticle

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