Efficacy of Colistin and Non-Colistin Monotherapies in Multi-Drug Resistant Acinetobacter Baumannii Bacteremia/Sepsis

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dc.authorid0000-0002-0244-4006
dc.authorid0000-0002-8977-5931
dc.authorid0000-0002-1104-8232
dc.authorid0000-0003-0502-432X
dc.authorid0000-0003-1514-1685
dc.authorwosidÖrmen, Bahar/ABA-1027-2021
dc.authorwosidDurdu, Bulent/I-7851-2016
dc.authorwosidbalkan, ilker inanc/AAI-1578-2019
dc.authorwosidARSLAN, FERHAT/ABG-5757-2021
dc.authorwosidOztoprak, Nefise/AAD-2679-2019
dc.authorwosidKilic, Aysegul Ulu/AAM-1069-2021
dc.authorwosidHatipoğlu, Çiğdem Ataman/AAA-4135-2021
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorAğalar, Canan
dc.contributor.authorAkalın, Şerife
dc.contributor.authorAlici, Özlem
dc.contributor.authorYılmaz, Hava
dc.contributor.authorDoğan, Mustafa
dc.date.accessioned2022-05-11T14:37:22Z
dc.date.available2022-05-11T14:37:22Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: This retrospective study aimed to investigate the efficacies of colistin and non-colistin monotherapies in multi-drug resistant Acinetobacter baumannii bacteremia (MDR-AB). Materials and methods: Cases with MDR-AB from 27 tertiary-referral hospitals between January 2009 and December 2012 were included. Patients' data that were on either colistin monotherapy (CM) or non-colistin monotherapy (NCM) were compared. Mortality on Day 14 was the primary endpoint, whereas microbiological eradication and clinical outcome were the secondary ones. Results: Eighty-four cases were included in the study with 36 being in the CM group and 48 in the NCM group. Thirty-eight (452%) cases were male and the mean age was 602 years. The mean durations of pre-MDR-AB hospital stay and intensive care unit stay were 25.8 days and 20.9 days, respectively. All of the cases had fever (>38 degrees C). The mean Pitt bacteremia score (PBS) of the patients was calculated as 6.8, APACHE 2 score as 18.9 and the Charlson co-morbidity index (CCI) as 3.7 (CM: 3.6 vs. NCM: 3.9). Twenty (55.6%) cases in the CM group and 26 cases in the NCM group (542%) (p=0.81) died; 9 cases in the CM group (25%) and 16 cases in the NCM group (33 3%) had treatment failure (P=0.55). Bacteriological eradication was achieved in 20 (55.6%) cases in the CM group and in 36 cases (75%) in the NCM group (P=0.061). Conclusions: No significant difference could be identified between the colistin monotherapy and non-colistin monotherapy options in MDR-AB cases with respect to the results of efficacy and 14-day mortality.
dc.identifier.endpage1143
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84907520572
dc.identifier.scopusqualityN/A
dc.identifier.startpage1137
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8671
dc.identifier.volume30
dc.identifier.wosWOS:000364114800027
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcinetobacter baumannii
dc.subjectbacteremia
dc.subjectcolistin
dc.subjectmonotherapy
dc.subjectmulti-drug resistant
dc.subjectsepsis
dc.subjectCombination Therapy
dc.subjectClinical Impact
dc.subjectRisk-Factors
dc.subjectInfections
dc.subjectAmpicillin
dc.subjectSulbactam
dc.subjectEmergence
dc.subjectVs.
dc.titleEfficacy of Colistin and Non-Colistin Monotherapies in Multi-Drug Resistant Acinetobacter Baumannii Bacteremia/Sepsis
dc.typeArticle

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