Cardiorespiratory findings in epilepsy: A recent review on outcomes and pathophysiology

Basit Öğe Kaydı
dc.authorid0000-0001-9865-6224
dc.authorid0000-0003-0993-5622
dc.authorid0000-0002-3942-2097
dc.authorid0000-0002-7444-6932
dc.authorscopusid57200989999
dc.authorscopusid57216899438
dc.authorscopusid57222640358
dc.authorscopusid57220304990
dc.authorscopusid37034995600
dc.authorwosidShaikh, Mohd. Farooq/H-6029-2019
dc.authorwosidArulsamy, Alina/AAU-9166-2021
dc.authorwosidSinha, Jitendra Kumar/AAZ-5040-2020
dc.authorwosidAKYUZ, Enes/W-7801-2018
dc.contributor.authorAkyüz, Enes
dc.contributor.authorÜner, Arda Kaan
dc.contributor.authorKöklü, Betül
dc.contributor.authorArulsamy, Alina
dc.contributor.authorShaikh, Mohd. Farooq
dc.date.accessioned2022-05-11T14:48:27Z
dc.date.available2022-05-11T14:48:27Z
dc.date.issued2021
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractEpilepsy is a debilitating disorder of uncontrollable recurrent seizures that occurs as a result of imbalances in the brain excitatory and inhibitory neuronal signals, that could stem from a range of functional and structural neuronal impairments. Globally, nearly 70 million people are negatively impacted by epilepsy and its comorbidities. One such comorbidity is the effect epilepsy has on the autonomic nervous system (ANS), which plays a role in the control of blood circulation, respiration and gastrointestinal function. These epilepsy-induced impairments in the circulatory and respiratory systems may contribute toward sudden unexpected death in epilepsy (SUDEP). Although, various hypotheses have been proposed regarding the role of epilepsy on ANS, the linking pathological mechanism still remains unclear. Channelopathies and seizure-induced damages in ANS-control brain structures were some of the causal/pathological candidates of cardiorespiratory comorbidities in epilepsy patients, especially in those who were drug resistant. However, emerging preclinical research suggest that neurotransmitter/receptor dysfunction and synaptic changes in the ANS may also contribute to the epilepsy-related autonomic disorders. Thus, pathological mechanisms of cardiorespiratory dysfunction should be elucidated by considering the modifications in anatomy and physiology of the autonomic system caused by seizures. In this regard, we present a comprehensive review of the current literature, both clinical and preclinical animal studies, on the cardiorespiratory findings in epilepsy and elucidate the possible pathological mechanisms of these findings, in hopes to prevent SUDEP especially in patients who are drug resistant.
dc.identifier.doi10.1002/jnr.24861
dc.identifier.endpage2073
dc.identifier.issn0360-4012
dc.identifier.issn1097-4547
dc.identifier.issue9en_US
dc.identifier.pmid34109651
dc.identifier.scopus2-s2.0-85107555910
dc.identifier.scopusqualityQ2
dc.identifier.startpage2059
dc.identifier.urihttps://doi.org/10.1002/jnr.24861
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10644
dc.identifier.volume99
dc.identifier.wosWOS:000659261400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKöklü, Betül
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Neuroscience Research
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectautonomic dysfunction
dc.subjectbrainstem
dc.subjectECG
dc.subjectheart
dc.subjectSUDEP
dc.subjectSudden Unexpected Death
dc.subjectHeart-Rate-Variability
dc.subjectGeneralized Eeg Suppression
dc.subjectAutonomic Nervous-System
dc.subjectTemporal-Lobe Epilepsy
dc.subjectTonic-Clonic Seizures
dc.subjectRespiratory Dysfunction
dc.subjectP-Glycoprotein
dc.subjectIctal Hypoxemia
dc.subjectKindling Model
dc.titleCardiorespiratory findings in epilepsy: A recent review on outcomes and pathophysiology
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10644.pdf
Boyut:
841.07 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu