Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes

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dc.authorid0000-0002-9435-8139
dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid57193693689
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidOZTURK, Samil/Q-4515-2019
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorÖztürk, Şamil
dc.date.accessioned2022-05-11T14:41:25Z
dc.date.available2022-05-11T14:41:25Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractCadmium (Cd) is one of the environmental pollutants affecting various tissues and organs including testis. The aim of this study was to investigate the anti-apoptotic effects of curcumin (Cur) on Cd-induced apoptosis in rat testes. The rats were randomly allotted into one of three experimental groups: control, Cd treated and Cd treated with Cur; each group contained 10 animals. The control group received 2 ml/day of dimethyl sulfoxide (DMSO). To induce toxicity, Cd (1 mg/kg body weight) was dissolved in normal saline and subcutaneously injected into rats for 4 weeks. The rats in Cur-treated group was given a daily dose of 100 mg/kg of Cur for 4 weeks. To date, no examinations of the anti-apoptotic properties of Cur on Cd-induced apoptosis in rat testes have been reported. The mean seminiferous tubule diameter, mean testicular biopsy score values and serum testosterone levels were significantly decreased in Cd-treated groups were compared to the control group. Furthermore, the Cur-treated animals showed an improved histological appearance and serum testosterone levels in Cd-treated group. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in testis tissues of the Cd-treated group with Cur therapy. The present study showed that Cur treatment protected testes against toxic effects of Cd. We believe that further preclinical research into the utility of Cur may indicate its usefulness as a potential treatment on the spermatogenesis after testicular injury caused by Cd-treated rats.
dc.identifier.doi10.1177/0748233711407242
dc.identifier.endpage130
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid21632575
dc.identifier.scopus2-s2.0-84859018306
dc.identifier.scopusqualityQ3
dc.identifier.startpage122
dc.identifier.urihttps://doi.org/10.1177/0748233711407242
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9178
dc.identifier.volume28
dc.identifier.wosWOS:000300222800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectcurcumin
dc.subjectTUNEL
dc.subjecttestes
dc.subjecttestosterone
dc.subjectInduced Lipid-Peroxidation
dc.subjectSprague-Dawley Rats
dc.subjectGerm-Cell Apoptosis
dc.subjectLeydig-Cells
dc.subjectStrand Breaks
dc.subjectShort-Term
dc.subjectZinc
dc.subjectToxicity
dc.subjectProtein
dc.subjectDamage
dc.titleAnti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes
dc.typeArticle

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