Serum Trace Elements in Type 2 Diabetes Mellitus

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dc.authorid0000-0001-7213-9624
dc.authorid0000-0001-7213-9624
dc.authorscopusid56290776600
dc.authorscopusid56291092000
dc.authorscopusid23968920100
dc.authorscopusid57076142800
dc.authorscopusid6508166517
dc.authorscopusid8713588200
dc.authorwosiderman, hande/AAZ-7697-2021
dc.authorwosiderman, hande/AAP-6507-2021
dc.authorwosidBOYUK, BANU/ABA-7026-2021
dc.contributor.authorAtalay, Hande
dc.contributor.authorBoyuk, Banu
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAltay, Murat
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorAydemir, Birsen
dc.date.accessioned2022-05-11T14:14:05Z
dc.date.available2022-05-11T14:14:05Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractStudies suggested that imbalances of several trace elements may play an important role in normal glucose and insulin metabolism. The aim of the present study was to evaluate changes in serum levels of copper, zinc, iron, and magnesium in patients with type 2 diabetes mellitus (T2DM) and their effect on glycemic control. Sixty female patients with T2DM and seventeen healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and control groups. Trace elements were studied using an atomic absorption spectrometer. Correlation analyses of trace elements with metabolic parameters were analyzed using Spearman's Rho correlation coefficient. T2DM patients had a significantly high fasting plasma glucose, glycated hemoglobin (HbA1C), and microalbuminuria levels (p< 0.05). Serum magnesium levels were significantly lower in patients with T2DM compared with the healthy controls (2.0 +/- 0.2 ng/mL vs. 2.3 +/- 0.2 ng/mL, p< 0.05). Serum copper levels showed a negative correlation with diabetes duration (r= -0.338, p= 0.011), and iron levels were negatively correlated with body mass index and C-reactive protein (r= -0.407, p= 0.009; r= -0.390, p= 0.017). Serum magnesium levels indicated a correlation with HbA1C and creatinine clearance (r= -0.371, p= 0.049; r= -0.462, p= 0.023), but no significant correlation was found with any of the other variables and zinc levels. The present study found low levels of magnesium, iron, copper, and zinc in women with T2DM, which supports a close relationship of the above trace elements with glucose metabolism. Low magnesium levels has been linked to poor glycemic control in T2DM; therefore, magnesium deficiency should be prevented in patients with diabetes.
dc.identifier.doi10.19193/0393-6384_2017_5_117
dc.identifier.endpage800
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85021737402
dc.identifier.scopusqualityN/A
dc.identifier.startpage795
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2017_5_117
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5779
dc.identifier.volume33
dc.identifier.wosWOS:000405777000011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKızıler, Ali Rıza
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes
dc.subjecttrace elements
dc.subjectHbA1C
dc.subjectMagnesium-Deficiency
dc.subjectInsulin-Resistance
dc.subjectOxidative Stress
dc.subjectZinc
dc.subjectCopper
dc.subjectHypomagnesemia
dc.subjectPathogenesis
dc.subjectMetabolism
dc.subjectManganese
dc.subjectFerritin
dc.titleSerum Trace Elements in Type 2 Diabetes Mellitus
dc.typeArticle

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