Synthesis and A Suggestion Mechanism on Biological Evaluation of Amino Acid-Schiff Base Ligands and Co(II), Cu(II) and Ni(II) Complexes

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dc.authorid0000-0002-3153-1328
dc.authorscopusid57303187700
dc.authorscopusid56800873300
dc.authorscopusid14043469100
dc.authorscopusid7003536574
dc.authorwosidAynacı Koyuncu, Elif/ABA-8632-2021
dc.authorwosidKaraboga, Munteha Nur Sonuc/ABA-6419-2020
dc.authorwosidSARI, NURSEN/AAA-8328-2021
dc.contributor.authorKoyuncu, E. Aynaci
dc.contributor.authorKaraboğa, Munteha Nur Sonuç
dc.contributor.authorLogoglu, E.
dc.contributor.authorSarı, N.
dc.date.accessioned2022-05-11T14:48:40Z
dc.date.available2022-05-11T14:48:40Z
dc.date.issued2016
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractThis study aimed to investigate of the antimicrobial activities of some amino acid-Schiff bases complexes as theoretical aspects. Co(II), Cu(II) and Ni(II) complexes of N, N'-(1,4-phenylenedimetiliden) bis DL-Alanine and N, N'-(1,4-phenylendimetiliden) bis DL-Glisine were been prepared and characterized. The antibacterial and antifungal activities were measured by Disc diffusion and MIC method against gram-positive bacteria i. e. Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium(clinical isolate), gram-negative bacteria Micrococcus Luteus NRRLB and as fungus Candida albicans. The antibiogram tests of amino acid-Schiff bases complexes showed better results than some known antibiotics. Especially Cu(II) complexes were more potent bacteridal than all of the substances synthesized. Furthermore a mechanism of reaction was offered in the explanation of these observation. Some of the compounds exhibited activity comparable to Ketoconazole, Ampicillin, Tetracycline, Penicillin, Gentamisin and Chloroamphenicol.
dc.description.sponsorshipGazi University Scientific Research FundGazi University [05/2007-02, 05/2010-03]
dc.description.sponsorshipThe authors thank to the Gazi University Scientific Research Fund (Project number: 05/2007-02 and 05/2010-03) for the financial support provided for this study and Ozge Cicek, Esra Yildirim, Yasemin Sahin and Refiye Tekiner for carryings out laboratory studies.
dc.identifier.endpage307
dc.identifier.issn2147-1762
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84975140620
dc.identifier.scopusqualityQ3
dc.identifier.startpage303
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10671
dc.identifier.volume29
dc.identifier.wosWOS:000378738800010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaraboğa, Munteha Nur Sonuç
dc.language.isoen
dc.publisherGazi Univ
dc.relation.ispartofGazi University Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSchiff base
dc.subjectAmino acid
dc.subjectMetal complexes
dc.subjectAntimicrobial activity
dc.subjectRadical
dc.subjectZinc Superoxide-Dismutase
dc.subjectAntimicrobial Activity
dc.subjectHydrogen-Peroxide
dc.subjectConductivity
dc.subjectOxidation
dc.subjectCopper
dc.subjectWater
dc.titleSynthesis and A Suggestion Mechanism on Biological Evaluation of Amino Acid-Schiff Base Ligands and Co(II), Cu(II) and Ni(II) Complexes
dc.typeArticle

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