Evaluation of Antidepressant Choices for the Treatment of Depressive Symptoms in Patients with Bipolar Disorder

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dc.authorid0000-0002-8514-0576
dc.authorid0000-0002-6626-1874
dc.authorwosidAtagun, Murat Ilhan/A-6386-2018
dc.authorwosidGuloksuz, Sinan/AAH-1076-2019
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorYesilyurt, Sema
dc.contributor.authorYeşilbaş, Dilek
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorOral, Timucin
dc.date.accessioned2022-05-11T14:41:02Z
dc.date.available2022-05-11T14:41:02Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Antidepressants are thought to cause manic switches and accelerate cycling in the treatment of bipolar depression. On the other hand, other evidence suggests that antidepressant neither cause manic switches, nor are effective for the treatment of bipolar depression. This study aimed to assess clinicians' attitudes towards antidepressant choices for treatment of bipolar depressive episodes and subthreshold depression. Methods: Medical records of 784 patients with bipolar disorder were investigated retrospectively. Antidepressants were used in 55 of 263 depressive episodes (20.9%). Data regarding 78 episodes (23 subthreshold symptoms, 55 episodes) of 68 patients (54 female, 14 male; mean age: 39.64 +/- 10.99) were obtained. Descriptive statistics were the evaluation method. Results: In our department, antidepressants were used in 20.9% of the patients in the treatment of bipolar depression. One third of patients receiving antidepressant prescriptions had a history of manic switch, 5 (21.7%) of the patients with subthreshold symptoms receiving antidepressant prescriptions had a history of manic switch. However, manic switch occurred in only 5 (6.4%) patients. Selective serotonin reuptake inhibitors were the most common cause (58.3%) of the manic switch in patients with a history of manic switch. Discussion: Clinicians are still using antidepressants in the treatment of bipolar depression. Antidepressants targeting many neurotransmitter systems can be used in the first line treatments and antidepressants can be used even in patients with a history of manic switch. This controversial topic should be studied prospectively with larger samples and it must be clarified whether this phenomenon is a natural course of the disorder or triggered by antidepressant medications.
dc.identifier.doi10.5350/DAJPN2012250208
dc.identifier.endpage156
dc.identifier.issn1018-8681
dc.identifier.issn1309-5749
dc.identifier.issue2en_US
dc.identifier.startpage151
dc.identifier.urihttps://doi.org/10.5350/DAJPN2012250208
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9035
dc.identifier.volume25
dc.identifier.wosWOS:000421424600009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAtagün, Murat İlhan
dc.language.isoen
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A S
dc.relation.ispartofDusunen Adam-Journal of Psychiatry and Neurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBipolar depression
dc.subjectantidepressants
dc.subjectmanic switch
dc.titleEvaluation of Antidepressant Choices for the Treatment of Depressive Symptoms in Patients with Bipolar Disorder
dc.typeArticle

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