Effects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats

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dc.authorid0000-0002-1218-0745
dc.authorscopusid55116304900
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid36696857400
dc.authorscopusid16043836500
dc.authorscopusid36633054800
dc.contributor.authorOğuz, Serhat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorToydemir, Toygar
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorOnur, Hatice
dc.date.accessioned2022-05-11T14:41:28Z
dc.date.available2022-05-11T14:41:28Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe present study was performed to investigate the effect of Urtica dioica (UD) on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated, PH and PH+UD; each group contains eight animals. The rats in UD-treated groups were given UD oils (2ml/kg/day) once a day orally for 7days starting 3days prior to hepatectomy operation. At day 7 after resection, liver samples were collected. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated deoxyuridine triphosphate nick end-labeling assay, apoptotic index (AI) were evaluated at day 7 after hepatectomy. As a result, UD significantly increased MI and PI, significantly decreased AI and also attenuated hepatic vacuolar degeneration and sinusoidal congestion in PH rats. UD treatment significantly decreased the elevated tissue MDA level and increased the reduced SOD activity and GSH level in the tissues. These results suggest that UD pretreatment was beneficial for rat liver regeneration after partial hepatectomy.
dc.identifier.doi10.1177/0748233713480211
dc.identifier.endpage484
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue5en_US
dc.identifier.pmid23456814
dc.identifier.scopus2-s2.0-84930453171
dc.identifier.scopusqualityQ3
dc.identifier.startpage475
dc.identifier.urihttps://doi.org/10.1177/0748233713480211
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9188
dc.identifier.volume31
dc.identifier.wosWOS:000354022800012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUD
dc.subjectpartial hepatectomy
dc.subjectoxidative stress
dc.subjectimmunohistochemistry
dc.subjectTUNEL
dc.subjectrat
dc.subjectCell Nuclear Antigen
dc.subjectLiver-Regeneration
dc.subjectLipid-Peroxidation
dc.subjectHepatocellular-Carcinoma
dc.subjectSuperoxide-Dismutase
dc.subjectGrowth-Factor
dc.subjectVitamin-E
dc.subjectAntioxidant
dc.subjectHepatocyte
dc.subjectPathology
dc.titleEffects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats
dc.typeArticle

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