Serum YKL-40: a potential biomarker for psoriasis or endothelial dysfunction in psoriasis?

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dc.authorid0000-0003-0000-5568
dc.authorscopusid27867662800
dc.authorscopusid23968920100
dc.authorscopusid6505680586
dc.authorscopusid55414483000
dc.authorscopusid55413116500
dc.authorscopusid55481926000
dc.authorscopusid37058172000
dc.authorwosidErfan, Gamze/W-8139-2018
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorErfan, Gamze
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorRifaioğlu, Emine Nur
dc.contributor.authorKaya, Şule
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorKulaç, Mustafa
dc.date.accessioned2022-05-11T14:07:45Z
dc.date.available2022-05-11T14:07:45Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractPsoriasis is a disease that can contribute to a risk of atherosclerosis. In several studies, impaired endothelial dysfunction (ED) is correlated with psoriasis. Serum YKL-40 is a new inflammatory biomarker of vascular damage, like ED and cardiovascular diseases. The aim of the study was to compare relevance of serum YKL-40 levels in psoriasis patients and healthy subjects according to ED diagnosis and identifiable cardiovascular risk factors. Sixty (31 female, 29 male) patients with plaque psoriasis, and 30 (18 female, 12 male) healthy controls were selected according to whether they had at least one or no identifiable risk factors for cardiovascular disease. All subjects were evaluated ultrasonographically for endothelial function and diagnosed as with or without ED and all groups compared for serum YKL-40 levels. YKL-40 levels of psoriatic patients with ED were higher than healthy controls with ED (P = < 0.05). There were no statistical differences in between subjects without ED. YKL-40 levels of patients over age of 40 were higher than younger ones (P < 0.05). But in healthy controls, there were no differences. In comparison of cardiovascular risk-positive (RP) patients and RP healthy subjects, YKL-40 levels were higher in RP patients (P = < 0.05). The elevation of plasma YKL-40 in psoriasis can be associated not only with inflammation of the disease, but also with ED. YKL-40 can be used as a marker for predicting and preventing cardiovascular diseases in RP psoriatic patients with age above 40.
dc.identifier.doi10.1007/s11010-014-2277-y
dc.identifier.endpage212
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue45323en_US
dc.identifier.pmid25421412
dc.identifier.scopus2-s2.0-84922105951
dc.identifier.scopusqualityQ2
dc.identifier.startpage207
dc.identifier.urihttps://doi.org/10.1007/s11010-014-2277-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5191
dc.identifier.volume400
dc.identifier.wosWOS:000347530100022
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErfan, Gamze
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorRifaioğlu, Emine Nur
dc.institutionauthorKaya, Şule
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorKulaç, Mustafa
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular and Cellular Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPsoriasis
dc.subjectYKL-40
dc.subjectEndothelial dysfunction
dc.subjectCardiovascular risk
dc.subjectCoronary-Artery
dc.subjectInflammation
dc.subjectAssociation
dc.subjectAtherosclerosis
dc.subjectMigration
dc.subjectDiseases
dc.subjectMarker
dc.subjectGp38k
dc.titleSerum YKL-40: a potential biomarker for psoriasis or endothelial dysfunction in psoriasis?
dc.typeArticle

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