Out-of-Reference Range Thyroid-Stimulating Hormone Levels in Levothyroxine-Treated Primary Hypothyroid Patients: A Multicenter Observational Study

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dc.authorid0000-0002-6569-8142
dc.authorid0000-0002-1286-2172
dc.authorid0000-0002-0075-6313
dc.authorid0000-0002-6231-0034
dc.authorscopusid7003531672
dc.authorscopusid24069390000
dc.authorscopusid16022067500
dc.authorscopusid13407057000
dc.authorscopusid35190979600
dc.authorscopusid16175846400
dc.authorscopusid54987367600
dc.authorwosidUygur, Meliha Melin/AAJ-5766-2021
dc.authorwosidYalın, Serap/L-7402-2017
dc.authorwosidGogas Yavuz, Dilek/AAC-3697-2020
dc.authorwosidSarac, Fulden/AAA-9040-2021
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.contributor.authorGöğaş Yavuz, Dilek
dc.contributor.authorYazıcı, Dilek
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorAtmaca, Ayşegül
dc.contributor.authorSancak, Seda
dc.contributor.authorSaraç, Fulden
dc.contributor.authorAsmaz, Özlem
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2022-05-11T14:39:55Z
dc.date.available2022-05-11T14:39:55Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Although levothyroxine (LT4) replacement therapy for hypothyroidism has been established as safe, inexpensive and effective, many studies from different countries reported out-of-reference range thyroid-stimulating hormone (TSH) values for the hypothyroid patients under LT4 treatment. The aim of this study was to determine TSH levels of primary hypothyroid patients under LT4 treatment and to assess self-reported compliance with daily LT4 intake in tertiary care centers in Turkey. Design: In this cross-sectional, observational study, adult patients with primary hypothyroidism, receiving LT4 treatment for at least 6 months, were included. The patients were from 12 tertiary care centers in 9 cities of Turkey. TSH and free T4 levels were recorded from patient files and self-reported compliance with daily LT4 intake was assessed by interviewing the subjects at the last visit. Results: A total of 1,755 subjects (46 +/- 13 years; F/M: 89.9/10.1%) with primary hypothyroidism were enrolled. Of the hypothyroid subjects, 44.8% had out-of-reference range serum TSH levels. TSH values were over the reference range (TSH > 4 mIU/L) in 26.2% and were under the reference range (TSH < 0.5 mIU/L) in 18.6% of the patients. Total duration of LT4 treatment was 5.9 +/- 4.7 years and mean dose was 1.2 +/- 0.6 mu g/kg/day. Non-compliant patients (31.1%) had higher TSH levels (6.9 +/- 16 vs 3.8 +/- 0.9 mIU/L, P = 0.01) compared to compliant patients. Conclusion: The results of this study revealed that nearly half of the hypothyroid patients had out-of-reference range serum TSH values, despite under LT4 treatment. Compliance with LT4 treatment seems to be one of the major determinants to reach the target TSH levels in hypothyroid patients.
dc.identifier.doi10.3389/fendo.2017.00215
dc.identifier.issn1664-2392
dc.identifier.pmid28955301
dc.identifier.scopus2-s2.0-85029714553
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fendo.2017.00215
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8797
dc.identifier.volume8
dc.identifier.wosWOS:000410277300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Murat
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypothyroidism
dc.subjectlevothyroxine
dc.subjecttarget thyroid-stimulating hormone
dc.subjectthyroid-stimulating hormone
dc.subjectprimary hypothyroidism
dc.subjectcompliance
dc.subjectL-Thyroxine
dc.subjectPylori Infection
dc.subjectAbsorption
dc.subjectTherapy
dc.subjectDisease
dc.subjectReplacement
dc.subjectPrevalence
dc.subjectCommunity
dc.titleOut-of-Reference Range Thyroid-Stimulating Hormone Levels in Levothyroxine-Treated Primary Hypothyroid Patients: A Multicenter Observational Study
dc.typeArticle

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