Decreased serum allopregnanolone and progesterone levels in male patients with bipolar disorder and their effects on cognitive functions

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dc.contributor.authorKarademir, Mihrali
dc.contributor.authorBeyazyuz, Elmas
dc.contributor.authorBeyazyuz, Murat
dc.contributor.authorYilmaz, Ahsen
dc.contributor.authorAlbayrak, Yakup
dc.date.accessioned2024-10-29T17:58:18Z
dc.date.available2024-10-29T17:58:18Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe progression of bipolar disorder (BD) is characterized by recurrent episodes of depression, mania, and hypomania, thus affecting the daily functionality of individuals. Previous studies have shown that a large proportion of patients diagnosed with BD who are in clinical remission experience significant functional disorders. The present study aimed to investigate the relationships between cognitive impairment and serum progesterone, allopregnanolone and BDNF levels in male bipolar disorder patients who are in the euthymic period. Our study included 41 euthymic male patients with bipolar disorder and 40 age, sex, body mass index (BMI) and smoking-matched male healthy control subjects. Neuropsychiatric tests such as the Stroop Test TBAG Form, Auditory Verbal Digit Span Test- Form B (VADS-B) and Cancellation Test were administered to all participants, and 5-7 ml of peripheral venous blood sample was taken from all participants. Serum allopregnanolone, progesterone and BDNF levels were also measured in all participants. Serum allopregnanolone and progesterone levels were found to be lower in bipolar patients, and it was observed that the serum level of allopregnanolone decreased as the disease duration increased. The serum BDNF levels were similar between groups. The cognitive functions assessed using the Stroop, VADS-B and cancellation tests were found to be better in healthy subjects. The neurocognitive test performances of all participants were strongly positively correlated with allopregnanolone levels. The present study supports the hypothesis that allopregnanolone acts as an endogenous mood stabilizer.
dc.identifier.doi10.1007/s00406-023-01607-9
dc.identifier.endpage524
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.issue3en_US
dc.identifier.pmid37086304
dc.identifier.scopus2-s2.0-85153316763
dc.identifier.scopusqualityQ1
dc.identifier.startpage515
dc.identifier.urihttps://doi.org/10.1007/s00406-023-01607-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14204
dc.identifier.volume274
dc.identifier.wosWOS:000973381900002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAllopregnanolone
dc.subjectBipolar
dc.subjectBDNF
dc.subjectCognitive
dc.subjectProgesterone
dc.titleDecreased serum allopregnanolone and progesterone levels in male patients with bipolar disorder and their effects on cognitive functions
dc.typeArticle

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