Is meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk

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dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorFazlioğlu, Nevin
dc.contributor.authorGüzel, Savaş
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorAydın, Cihan
dc.date.accessioned2023-05-06T17:17:04Z
dc.date.available2023-05-06T17:17:04Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractPurposeMetrnl, a newly discovered adipokine with significant expression in white adipose tissue, promotes energy expenditure and contributes to the development of cardiovascular disorders. Endocan is a surrogate marker for endothelial dysfunction and is linked to cardiovascular risk factors. Higher cardiovascular morbidity and mortality have been linked to obstructive sleep apnea (OSA). In this study, we investigated the potential of serum Metrnl and endocan as biomarkers to identify patients with OSA who are at increased cardiovascular risk and differentiate them from healthy controls.MethodsThe study included the evaluation of serum levels of endocan and Metrnl in individuals with OSA and healthy controls. All participants underwent full polysomnography to evaluate their sleep, and carotid intima-media thickness (CIMT) was measured in each of them.ResultsPatients with OSA (n = 117) had considerably lower levels of Metrnl and significantly higher levels of endocan than controls (n = 59). Once confounding factors were taken into account, both Metrnl and endocan were effective predictors of OSA. Additionally, the severity of OSA, as determined by the apnea-hypopnea index (AHI), was linked to Metrnl and endocan levels. The study also found a significant and independent inverse association between CIMT and Metrnl, along with a positive association with endocan after making multiple adjustments. Furthermore, there was a significant and independent connection between CIMT and AHI.ConclusionBased on these findings, Metrnl and endocan have the potential to be valuable markers for identifying patients with OSA who are at increased risk of early vascular damage.
dc.identifier.doi10.1007/s11325-023-02800-9
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.pmid36877355
dc.identifier.scopus2-s2.0-85149336063
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s11325-023-02800-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11811
dc.identifier.wosWOS:000944081700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorFazlioğlu, Nevin
dc.institutionauthorGüzel, Savaş
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorAydın, Cihan
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofSleep And Breathing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApnea-hypopnea index
dc.subjectBiomarkers
dc.subjectCarotid intima-media thickness
dc.subjectEndocan
dc.subjectMetrnl
dc.subjectObstructive sleep apnea
dc.subjectEndothelial Dysfunction
dc.subjectCardiovascular-Disease
dc.subjectOxidative Stress
dc.subjectMechanisms
dc.subjectEndocan
dc.subjectVersion
dc.subjectLevel
dc.titleIs meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk
dc.typeArticle

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