The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-a concentration and carotid intima-media thickness in women with polycystic ovary syndrome

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dc.authorscopusid6506061779
dc.authorscopusid24075279000
dc.authorscopusid23986422400
dc.authorscopusid23968920100
dc.authorscopusid6505680586
dc.authorscopusid55314067300
dc.authorscopusid55597937800
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAbalı, Remzi
dc.contributor.authorÇelik, Cem
dc.contributor.authorTaşdemir, Nice
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorYüksel, Aytaç
dc.contributor.authorÇelik, Elçin
dc.date.accessioned2022-05-11T14:10:00Z
dc.date.available2022-05-11T14:10:00Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractObjective: To investigate fetuin-A concentrations and its association with metabolic and sonographic cardiovascular markers in women with polycystic ovary syndrome (PCOS) and healthy subjects. Study design: Thirty-five women with PCOS and 37 healthy control women were matched for body mass index (BMI) and age. Serum fetuin-A concentrations, and reproductive and adrenal hormones were measured, and insulin resistance and carotid intima media thickness (CIMT) were evaluated in both groups. The correlations between cardiovascular risk factors, CIMT and fetuin-A concentrations were tested. Results: Mean fetuin-A concentrations were significantly elevated in the PCOS group compared with control subjects (101.2 ng/ml +/- 33.55 vs. 82.5 ng/ml +/- 32.65, P = 0.019). CIMT was also higher in women with PCOS than in control subjects (0.51 +/- 0.05 mm vs. 0.44 +/- 0.05 mm, P < 0.01). Serum lipid parameters were correlated to serum fetuin-A concentrations in the PCOS group, but no correlation was found between fetuin-A and CIMT (r(PCOS) = 0.244. p(PCOS) = 0.158; r(control) = 0.002, p(control) = 0.988). Conclusion: In this, the first study of fetuin-A concentrations in PCOS, the results showed that fetuin-A concentrations were increased in euglycemic patients with PCOS. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejogrb.2013.01.023
dc.identifier.endpage49
dc.identifier.issn0301-2115
dc.identifier.issue1en_US
dc.identifier.pmid23433744
dc.identifier.scopus2-s2.0-84879125041
dc.identifier.scopusqualityN/A
dc.identifier.startpage45
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2013.01.023
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5244
dc.identifier.volume169
dc.identifier.wosWOS:000321539300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAbalı, Remzi
dc.institutionauthorÇelik, Cem
dc.institutionauthorTaşdemir, Nice
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorÇelik, Elçin
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolycystic ovarian syndrome
dc.subjectFetuin-A
dc.subjectCarotid intima-media thickness
dc.subjectCardiovascular disease
dc.subjectInsulin resistance
dc.subjectCardiovascular Risk-Factors
dc.subjectFetuin-A
dc.subjectEndothelial Dysfunction
dc.subjectInsulin-Resistance
dc.subjectYoung-Women
dc.subjectFollow-Up
dc.subjectDisease
dc.subjectAccumulation
dc.subjectAssociation
dc.subjectPrevalence
dc.titleThe serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-a concentration and carotid intima-media thickness in women with polycystic ovary syndrome
dc.typeArticle

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