A Novel Combined Index of D-Dimer, Fibrinogen, Albumin, and Platelet (FDAPR) as Mortality Predictor of COVID-19

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dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorErdal, Berna
dc.contributor.authorYılmaz, A.
dc.date.accessioned2023-04-20T08:01:19Z
dc.date.available2023-04-20T08:01:19Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractBackground: In coronavirus disease 2019 (COVID-19) caused by SARSCoV2 viruses, coagulation abnormalities are strongly correlated between disease severity and mortality risk. Aims: The aim was to search for new indices to determine mortality risk. Fibrinogen times D-dimer to albumin times platelet ratio calculated with the formula (FDAPR index: ((Fibrinogen x D-dimer)/(Albumin x Platelet)) investigated as a mortality marker in COVID-19 patients. The hospitalization data of 1124 patients were analyzed from the electronic archive system. Hemogram, coagulation, and inflammatory markers were investigated in the study group. Materials and Methods: All statistical analyses like the student t-test, Mann-Whitney U, Kaplan-Meier, and Cox hazard ratio, were performed with the SPSS 22.0 program. Results: Prothrombin time was prolonged significantly in patients (P < 0.05) compared to healthy subjects (n = 30). D-dimer and fibrinogen were high, and albumin and platelet counts were low in COVID-19 patients (all, P < 0.001). When the data of 224 non-survivors and 900 survived patients were compared, D-dimer and fibrinogen were higher, and albumin and platelet lower (all, P < 0.001) compared to mild and severe patients. At the cut-off value of 0.49, the FDAPR index was performed with 89.1% sensitivity and 88.6% specificity. FDAPR index had the highest mortality predictive power (P < 0.01; HR = 5.366; 95% CI; 1.729-16.654). Conclusions: This study revealed that the FDAPR index could be used as a mortality marker of COVID-19 disease.
dc.identifier.doi10.4103/njcp.njcp_1633_21
dc.identifier.endpage1423
dc.identifier.issn1119-3077
dc.identifier.issue9en_US
dc.identifier.pmid36149199
dc.identifier.startpage1418
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_1633_21
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10864
dc.identifier.volume25
dc.identifier.wosWOS:000864018400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorDoğan, Mustafa
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorErdal, Berna
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomarker
dc.subjectCoagulation
dc.subjectD-Dimer
dc.subjectMortality
dc.subjectSars-Cov2
dc.subjectInfection
dc.titleA Novel Combined Index of D-Dimer, Fibrinogen, Albumin, and Platelet (FDAPR) as Mortality Predictor of COVID-19
dc.typeArticle

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